TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN): PART IV-10. TOXICITY OF METABOLITES OF MIOCAMYCIN: ACUTE TOXICITY OF Mb12 IN MICE

We evaluated acute toxicity and estimated LD50 values of Mb12, one of the main metabolites of MOM, in male and female mice after single oral administration. Observations were continued for 1 week after treatment. The LD50values were calculated according to LITCHFIELD-WILCOXON'S method. It is co...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1984/08/25, Vol.37(8), pp.1546-1548
Main Authors: YOKOTA, MASAYUKI, TAKEDA, UETO, ODAKI, MASUZO, SASAKI, HITOSHI, KAWAOTO, HARUO, ITOH, TAKASHI, KOEDA, TAKEMI
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - toxicity
Body Weight - drug effects
Female
Lethal Dose 50
Leucomycins - metabolism
Leucomycins - toxicity
Male
Mice
Miocamycin
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Summary:We evaluated acute toxicity and estimated LD50 values of Mb12, one of the main metabolites of MOM, in male and female mice after single oral administration. Observations were continued for 1 week after treatment. The LD50values were calculated according to LITCHFIELD-WILCOXON'S method. It is concluded that LD50 values of Mb12 were 5,750mg/kg (4,914.5-6,727.5mg/kg) in male mice and 4,950mg/kg (4, 194.9-5,841.0mg/kg) in female mice, respectively.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.37.1546