TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN): PART IV-10. TOXICITY OF METABOLITES OF MIOCAMYCIN: ACUTE TOXICITY OF Mb12 IN MICE

We evaluated acute toxicity and estimated LD50 values of Mb12, one of the main metabolites of MOM, in male and female mice after single oral administration. Observations were continued for 1 week after treatment. The LD50values were calculated according to LITCHFIELD-WILCOXON'S method. It is co...

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Published in:Japanese journal of antibiotics 1984/08/25, Vol.37(8), pp.1546-1548
Main Authors: YOKOTA, MASAYUKI, TAKEDA, UETO, ODAKI, MASUZO, SASAKI, HITOSHI, KAWAOTO, HARUO, ITOH, TAKASHI, KOEDA, TAKEMI
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - toxicity
Body Weight - drug effects
Female
Lethal Dose 50
Leucomycins - metabolism
Leucomycins - toxicity
Male
Mice
Miocamycin
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container_end_page 1548
container_issue 8
container_start_page 1546
container_title Japanese journal of antibiotics
container_volume 37
creator YOKOTA, MASAYUKI
TAKEDA, UETO
ODAKI, MASUZO
SASAKI, HITOSHI
KAWAOTO, HARUO
ITOH, TAKASHI
KOEDA, TAKEMI
description We evaluated acute toxicity and estimated LD50 values of Mb12, one of the main metabolites of MOM, in male and female mice after single oral administration. Observations were continued for 1 week after treatment. The LD50values were calculated according to LITCHFIELD-WILCOXON'S method. It is concluded that LD50 values of Mb12 were 5,750mg/kg (4,914.5-6,727.5mg/kg) in male mice and 4,950mg/kg (4, 194.9-5,841.0mg/kg) in female mice, respectively.
doi_str_mv 10.11553/antibiotics1968b.37.1546
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source Alma/SFX Local Collection
subjects Animals
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - toxicity
Body Weight - drug effects
Female
Lethal Dose 50
Leucomycins - metabolism
Leucomycins - toxicity
Male
Mice
Miocamycin
title TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN): PART IV-10. TOXICITY OF METABOLITES OF MIOCAMYCIN: ACUTE TOXICITY OF Mb12 IN MICE
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