TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN): PART IV-12. TOXICITY OF METABOLITES OF MIOCAMYCIN: SUBACUTE TOXICITY OF Mb12 IN RATS

Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens1, 2). It is reported that MOM has the most interesting antibacterial properties among macrolide antibiotics3, 4) and is metabolized into 4 main metabolites of Mb1, Mb2,...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1984/08/25, Vol.37(8), pp.1552-1564
Main Authors: YOKOTA, MASAYUKI, TAKEDA, UETO, ODAKI, MASUZO, SASAKI, HITOSHI, NIIZATO, TETSUTARO, KAWAOTO, HARUO, WATANABE, HIROSHI, ISHIWATARI, NOBUYOSHI, HAYASAKA, HIROYASU, KOEDA, TAKEMI
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - toxicity
Blood Chemical Analysis
Body Weight - drug effects
Eating - drug effects
Female
Hematologic Tests
Kidney - pathology
Leucomycins - metabolism
Leucomycins - toxicity
Liver - pathology
Male
Miocamycin
Organ Size - drug effects
Rats
Rats, Inbred Strains
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Summary:Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens1, 2). It is reported that MOM has the most interesting antibacterial properties among macrolide antibiotics3, 4) and is metabolized into 4 main metabolites of Mb1, Mb2, Mb6, and Mb125). It is also known that LD0 values of Mb12 were estimated more than 5,000mg/kg without exhibiting any manifest toxic effects after single oral administration to male and female rats6). The object of this study was to examine toxicological effects in male and female rats after repeated oral administration of Mb12, a metabolite of MOM, for 5 weeks at a daily dosage of 125, 250, 500 and 1,000mg/kg which were selected in consideration of the maximum tolerable dosage level of 1,000mg/kg/day in MOM rat subacute toxicity studies as previously reported7).
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.37.1552