Frequency-Dependent Activation of Glucose Utilization in the Superior Cervical Ganglion by Electrical Stimulation of Cervical Sympathetic Trunk

Electrical stimulation of the distal stump of the transected cervical sympathetic trunk produces a frequency-dependent activation of glucose utilization, measured by the deoxy[14C]glucose method, in the superior cervical ganglion of the urethane-anesthetized rat. The frequency dependence falls betwe...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1983-07, Vol.80 (13), p.4179-4183
Main Authors: Yarowsky, Paul, Kadekaro, Massako, Sokoloff, Louis
Format: Article
Language:English
Subjects:
Anesthesia
Animals
Autoradiography
Biological Transport, Active
Blood plasma
Carbon Radioisotopes
Deoxy Sugars - metabolism
Deoxyglucose - metabolism
Electric Stimulation
Electrical stimulation
Energy metabolism
Ganglia
Ganglia, Sympathetic - metabolism
Glucose - metabolism
Male
Metabolism
Nerve tissue
Nerves
Neurobiology
Rats
Rats, Inbred Strains
Superior cervical ganglion
Sympathetic Nervous System - physiology
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Summary:Electrical stimulation of the distal stump of the transected cervical sympathetic trunk produces a frequency-dependent activation of glucose utilization, measured by the deoxy[14C]glucose method, in the superior cervical ganglion of the urethane-anesthetized rat. The frequency dependence falls between 0-15 Hz; at 20 Hz the activation of glucose utilization is no greater than at 15 Hz. Deafferentation of the superior cervical ganglion by transection of the cervical sympathetic trunk does not diminish the rate of glucose utilization in the ganglion in the urethane-anesthetized rat. These results indicate that the rate of energy metabolism in an innervated neural structure is, at least in part, regulated by the impulse frequency of the electrical input to the structure, and this regulation may be an essential component of the mechanism of the coupling of metabolic activity to functional activity in the nervous system.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.80.13.4179