Endocardial Tumors in Rats Exposed to Durable Fibrous Materials

Endocardial tumors in the rat found in association with intrathoracic implantation of durable fibrous materials are reported here for the first time. In Osborne-Mendel female rats, endocardial tumors occurred in 3 of 50 rats associated with the implantation of fiberglass greater than 5 µm in length...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1983-11, Vol.71 (5), p.1067-1071
Main Authors: Hoch-Ligeti, Cornelia, Sass, Bernard, Sobel, Harold J., Stewart, Harold L.
Format: Article
Language:English
Subjects:
Age Factors
Animals
Asbestos
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Chemical agents
Endocardium
Female
Glass
Heart Neoplasms - etiology
Heart Septum
Heart Ventricles
Medical sciences
Particle Size
Rats
Tumors
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Summary:Endocardial tumors in the rat found in association with intrathoracic implantation of durable fibrous materials are reported here for the first time. In Osborne-Mendel female rats, endocardial tumors occurred in 3 of 50 rats associated with the implantation of fiberglass greater than 5 µm in length and 1–3 µm in diameter, in 1 of 15 rats associated with fiberglass of 0.03x3 µm, and in 1 of 15 rats associated with pulverized glass fiber. The intrathoracic administrations of pulverized chrysotile, of cigarette smoke condensate and crocidolite, and of coarse cotton lint, and of intravenous injections of air particulate extract were associated with endocardial tumor in 1 of 15 rats each. The dimensions of the durable fibers associated with endocardial tumors were similar to those of carcinogenic asbestos. Endocardial tumors were not observed in concurrently studied control rats.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/71.5.1067