Phototoxic reactions to piroxicam, naproxen and tiaprofenic acid

Photosensitivity investigations have been carried out using an irradiation monochromator on 31 patients taking one of seven different nonsteroidal anti-inflammatory agents for the treatment of rheumatoid and osteoarthritis. Six patients, who were taking either piroxicam, naproxen or tiaprofenic acid...

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Bibliographic Details
Published in:British journal of rheumatology 1983-11, Vol.22 (4), p.239-242
Main Authors: DIFFEY, B. L, DAYMOND, T. J, FAIRGREAVES, H
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - adverse effects
Anti-Inflammatory Agents - therapeutic use
Arthritis, Rheumatoid - drug therapy
Biological and medical sciences
Female
Humans
Injuries of the skin. Diseases of the skin due to physical agents
Male
Medical sciences
Naproxen - adverse effects
Osteoarthritis - drug therapy
Photosensitivity Disorders - chemically induced
Piroxicam
Propionates - adverse effects
Thiazines - adverse effects
Traumas. Diseases due to physical agents
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Summary:Photosensitivity investigations have been carried out using an irradiation monochromator on 31 patients taking one of seven different nonsteroidal anti-inflammatory agents for the treatment of rheumatoid and osteoarthritis. Six patients, who were taking either piroxicam, naproxen or tiaprofenic acid, experienced adverse immediate reactions of erythema and flaring, together with an urticarial response in four of these six patients. No phototoxic response was observed in patients taking either indomethacin, ketoprofen, benorylate or ibuprofen, although firm conclusions about the non-phototoxic nature of these four drugs cannot be drawn from this pilot study because of the small numbers of patients investigated.
ISSN:0263-7103
1460-2172