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O6-methylguanine removal by competent and incompetent human lymphoblastoid lines from the same male individual

Two cell lines, one proficient (Mex+) and one deficient (Mex-) in the ability to remove O6-methylguanine, have been isolated by Epstein-Barr virus-mediated transformation of a single blood sample obtained from a normal human male. Extracts of untreated cells differ in their O6-methylguanine transfer...

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Published in:	Cancer research (Chicago, Ill.) Ill.), 1983-07, Vol.43 (7), p.3316-3320
Main Authors:	SKLAR, R. M, STRAUSS, B. S
Format:	Article
Language:	English
Subjects:	Adenine - analogs & derivatives Adenine - isolation & purification Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cell Division - drug effects Cell Line Chemical agents Chromosome Aberrations Guanine - analogs & derivatives Guanine - isolation & purification Humans Karyotyping Lymphocyte Activation Lymphocytes - metabolism Male Medical sciences Methylnitronitrosoguanidine - pharmacology Tumors
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container_issue	7
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container_title	Cancer research (Chicago, Ill.)
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creator	SKLAR, R. M STRAUSS, B. S
description	Two cell lines, one proficient (Mex+) and one deficient (Mex-) in the ability to remove O6-methylguanine, have been isolated by Epstein-Barr virus-mediated transformation of a single blood sample obtained from a normal human male. Extracts of untreated cells differ in their O6-methylguanine transferase (methyl acceptor protein) activity. Although both lines arise from the same individual, they show great difference in their sensitivities to the toxic action of N-methyl-N'-nitro-N-nitrosoguanidine. Chromosome counts of the strains reveal a modal number of 46 for both. Neither X-inactivation nor a gross abnormality in chromosome number can be the cause of the difference between the two lines.
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M ; STRAUSS, B. S</creator><creatorcontrib>SKLAR, R. M ; STRAUSS, B. S</creatorcontrib><description>Two cell lines, one proficient (Mex+) and one deficient (Mex-) in the ability to remove O6-methylguanine, have been isolated by Epstein-Barr virus-mediated transformation of a single blood sample obtained from a normal human male. Extracts of untreated cells differ in their O6-methylguanine transferase (methyl acceptor protein) activity. Although both lines arise from the same individual, they show great difference in their sensitivities to the toxic action of N-methyl-N'-nitro-N-nitrosoguanidine. Chromosome counts of the strains reveal a modal number of 46 for both. 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Although both lines arise from the same individual, they show great difference in their sensitivities to the toxic action of N-methyl-N'-nitro-N-nitrosoguanidine. Chromosome counts of the strains reveal a modal number of 46 for both. Neither X-inactivation nor a gross abnormality in chromosome number can be the cause of the difference between the two lines.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>6850639</pmid><tpages>5</tpages></addata></record>
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source	Free E-Journal (出版社公開部分のみ）
subjects	Adenine - analogs & derivatives Adenine - isolation & purification Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cell Division - drug effects Cell Line Chemical agents Chromosome Aberrations Guanine - analogs & derivatives Guanine - isolation & purification Humans Karyotyping Lymphocyte Activation Lymphocytes - metabolism Male Medical sciences Methylnitronitrosoguanidine - pharmacology Tumors
title	O6-methylguanine removal by competent and incompetent human lymphoblastoid lines from the same male individual
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