A Transferrin Variant in a Kindred with Cystic Fibrosis

An electrophoretically fast transferrin (Tf) variant, TfB, was found in a cystic fibrosis homozygote. Since neither cystic fibrosis nor the transferrin structural gene has been mapped on human chromosomes, a study was made of this kindred. Genetic markers including ABO, MN, Rh, Fy blood groups and T...

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Bibliographic Details
Published in:Human heredity 1981-01, Vol.31 (4), p.248-251
Main Authors: Bowman, Barbara H., Barnett, Don R., Coppenhaver, Dorian
Format: Article
Language:English
Subjects:
Blood Group Antigens - genetics
Carrier Proteins - genetics
Chromosome Mapping
Cystic Fibrosis - genetics
Female
Genes
Genetic Linkage
Genetic Variation
Humans
Male
Original Paper
Original Papers
Pedigree
Transferrin - genetics
Vitamin D - genetics
Vitamin D-Binding Protein
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Summary:An electrophoretically fast transferrin (Tf) variant, TfB, was found in a cystic fibrosis homozygote. Since neither cystic fibrosis nor the transferrin structural gene has been mapped on human chromosomes, a study was made of this kindred. Genetic markers including ABO, MN, Rh, Fy blood groups and Tf, group-specific component, and haptoglobin serum protein polymorphisms were determined in available members of the kindred. The genes for cystic fibrosis and Tf appear to segregate independently in the kindred, although crossing-over between linked genes in the homozygous cystic fibrosis brother of the propositus could account for the genotypes observed.
ISSN:0001-5652
1423-0062
DOI:10.1159/000153217