Hepatocarcinogenicity of Sterigmatocystin and Versicolorin A to Rainbow Trout (Salmo Gairdneri) Embryos

Versicolorin A (VA) and sterigmatocystin (ST) are biosynthetic precursors of aflatoxin B1 (AFB1). The carcinogenicity of these compounds relative to AFB1 was determined with the use of rainbow trout (Salmo gairdneri) embryo exposure. Exposure of 14-day rainbow trout embryos to a 0.5-ppm aqueous susp...

Full description

Saved in:
Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1980-06, Vol.64 (6), p.1503-1509
Main Authors: Hendricks, Jerry D., Sinnhuber, Russell O., Wales, Joseph H., Stack, Michael E., Hsieh, Dennis P. H.
Format: Article
Language:English
Subjects:
Aflatoxins - toxicity
Animals
Anthraquinones - toxicity
Liver Neoplasms, Experimental - chemically induced
Liver Neoplasms, Experimental - pathology
Salmonidae - physiology
Sterigmatocystin - toxicity
Trout - embryology
Trout - physiology
Xanthenes - toxicity
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Versicolorin A (VA) and sterigmatocystin (ST) are biosynthetic precursors of aflatoxin B1 (AFB1). The carcinogenicity of these compounds relative to AFB1 was determined with the use of rainbow trout (Salmo gairdneri) embryo exposure. Exposure of 14-day rainbow trout embryos to a 0.5-ppm aqueous suspension of ST for 1 hour produced a 13% incidence of hepatocellular carcinomas among survivors 1 year later. Similar exposure of trout eggs to a 0.5-ppm solution of AFB, produced a 53% incidence among survivors. Subsequent exposure of 21-day rainbow trout embryos to 5- and 25-ppm solutions of VA resulted in hepatocellular carcinoma incidences among survivors of 42 and 88%, respectively, at 12 months. A 0.5-ppm AFB1 positive control group had a 88% incidence among survivors of hepatocellular carcinomas at 1 year. These results established the carcinogenicity of VA for the first time and confirmed previous reports of ST carcinogenicity. Both compounds were of sufficient potencies to warrant caution as possible human health hazards.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/64.6.1503