Methylazoxymethanol: Effect on the Immune Response of Rats to Human Serum Albumin

Inbred male F344 rats treated with 20 mg methylazoxymethanol (MAM)/kg body weight showed minimal damage to DNA in bone marrow, spleen, and thymus and no suppression of the humoral immune response to human serum albumin (HSA). At high doses of MAM (40, 60, and 80 mg/kg), damage to DNA of bone marrow,...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1982-04, Vol.68 (4), p.651-656
Main Authors: Habeeb, Ahmed F.S.A., Preston, Alan M., Sanabria, Priscila, Escobales, Nelson
Format: Article
Language:English
Subjects:
Animals
Antibodies - analysis
Antibody Formation - drug effects
Azo Compounds - pharmacology
Bone Marrow - drug effects
Bone Marrow - metabolism
DNA - metabolism
DNA Repair - drug effects
Dose-Response Relationship, Drug
Immunization
Male
Methylazoxymethanol Acetate - pharmacology
Rats
Rats, Inbred F344
Serum Albumin - administration & dosage
Serum Albumin - immunology
Spleen - drug effects
Spleen - metabolism
Thymus Gland - drug effects
Thymus Gland - metabolism
Time Factors
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Summary:Inbred male F344 rats treated with 20 mg methylazoxymethanol (MAM)/kg body weight showed minimal damage to DNA in bone marrow, spleen, and thymus and no suppression of the humoral immune response to human serum albumin (HSA). At high doses of MAM (40, 60, and 80 mg/kg), damage to DNA of bone marrow, spleen, and thymus was noted. The effect on the humoral immune responses was nonuniform. Some rats responded normally by eliciting precipitating antibodies, whereas others responded by synthesizing nonprecipitating antibodies at low levels. The production of nonprecipitating antibodies may indicate a restriction of the recognition of HSA antigenic determinants in rats given injections of MAM prior to immunization. The restriction may be a consequence of suppression or elimination of certain clones of lymphocytes responsible for recognition of certain antigenic determinants. This interference in some clones of lymphocytes would result in the synthesis of antibodies against one or two antigenic sites on the HSA and the concomitant inability of the produced antibodies to form complete lattice structure with antigen.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/68.4.651