Effect of estrogen on tumor-associated immunity in patients with adenocarcinoma of the prostate

Tumor-associated antigen-induced leukocyte adherence inhibition has been used as an in vitro criterion for evaluating the effect of estrogen on cell-mediated antitumor-associated immunity in patients with adenocarcinoma of the prostate. Significant (p less than 0.05) suppression from the reactivity...

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1978-11, Vol.38 (11 Pt 1), p.3702
Main Authors: Ablin, R J, Bhatti, R A, Guinan, P D
Format: Article
Language:English
Subjects:
Adenocarcinoma - drug therapy
Adenocarcinoma - immunology
Aged
Diethylstilbestrol - adverse effects
Diethylstilbestrol - analogs & derivatives
Humans
Immunity, Cellular - drug effects
Immunosuppression
In Vitro Techniques
Leukocyte Adherence Inhibition Test
Leukocytes - drug effects
Leukocytes - immunology
Male
Middle Aged
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - immunology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tumor-associated antigen-induced leukocyte adherence inhibition has been used as an in vitro criterion for evaluating the effect of estrogen on cell-mediated antitumor-associated immunity in patients with adenocarcinoma of the prostate. Significant (p less than 0.05) suppression from the reactivity obtained with untreated patients' leukocytes to allogeneic extracts of malignant prostatic tissue ranging from 19 to 80% was observed in all patients following preincubation of their leukocytes with diethylstilbesterol diphosphate. The observed suppression of tumor-associated immunity in the presence of exogenous estrogen provides further evidence to earlier studies that demonstrated estrogenic suppression of nonspecific cellular responsiveness as evaluated by phytohemagglutinin-induced lymphocytic blastogenesis of normal and prostatic cancer patients' lymphocytes and for the initially suggested concern over the efficacy of estrogenic therapy and its adverse effect on host cell-mediated immunological responsiveness.
ISSN:0008-5472