Glomerular basement membrane changes in aging nondiabetic and diabetic guinea pigs

Glomerular hyperplasia and thickening or the glomerular basement membrane increase with age in humans and animals. This glomerulopathy can be enhanced by hyperglycemic conditions such as diabetes mellitus. When diabetic guinea pigs were examined by fluorescent microscopy, deposits of a substance sim...

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Bibliographic Details
Published in:Experimental aging research 1981, Vol.7 (2), p.93-105
Main Authors: Langner, Paul H., Lang, C. Max, Singh, Suraj B., Munger, B. L., Abt, Arthur B.
Format: Article
Language:English
Subjects:
Aging
Animals
Basement Membrane - pathology
Diabetes Mellitus - immunology
Diabetes Mellitus - pathology
Diabetic Nephropathies - immunology
Fluorescent Antibody Technique
Glomerular Filtration Rate
Guinea Pigs
Hyperplasia - metabolism
Immunoglobulin G - analysis
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Summary:Glomerular hyperplasia and thickening or the glomerular basement membrane increase with age in humans and animals. This glomerulopathy can be enhanced by hyperglycemic conditions such as diabetes mellitus. When diabetic guinea pigs were examined by fluorescent microscopy, deposits of a substance similar to immunoglobulin G (IgG) were seen. Comparison with nondiabetic age-matched control animals suggest that glomerulopathy is related to aging, and can be further enhanced by hyperglycemia.
ISSN:0361-073X
1096-4657
DOI:10.1080/03610738108259792