Effect of the suspected tumor promoters saccharin, cyclamate, and phenol on nerve growth factor binding and response in cultured embryonic chick ganglia

The suspected bladder tumor promoters saccharin and cyclamate reversibly inhibited nerve growth factor-induced neurite outgrowth in embryonic chick sensory ganglia, and active concentrations of these artificial sweeteners inhibited binding of 125I-labeled mouse submaxillary gland nerve growth factor...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1982-02, Vol.42 (2), p.429
Main Author: Ishii, D N
Format: Article
Language:English
Subjects:
Animals
Axons - drug effects
Carcinogens - pharmacology
Chick Embryo
Culture Techniques
Cyclamates - pharmacology
Dose-Response Relationship, Drug
Ganglia - drug effects
Ganglia - embryology
Ganglia - metabolism
Mice
Nerve Growth Factors - metabolism
Peripheral Nerves - drug effects
Phenol
Phenols - pharmacology
Saccharin - pharmacology
Submandibular Gland - innervation
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Summary:The suspected bladder tumor promoters saccharin and cyclamate reversibly inhibited nerve growth factor-induced neurite outgrowth in embryonic chick sensory ganglia, and active concentrations of these artificial sweeteners inhibited binding of 125I-labeled mouse submaxillary gland nerve growth factor as well. The skin tumor promoter phenol also reversibly inhibited neurite outgrowth, while comparable concentrations of the nonpromoting but structurally related compounds benzene and fluorobenzene did not. However, in contrast to findings with saccharin and cyclamate, phenol had little, if any, effect on binding of radioactive nerve growth factor.
ISSN:0008-5472