CLINICAL STUDIES OF CEFOXITIN FOR THE TREATMENT OF RESPIRATORY TRACT INFECTIONS

A total of 42 patients who were suffering from respiratory tract infections were treated with cefoxitin, and the following results were obtained. 1.Out of 32 patients clinically evaluated, excellent or good responses were observed in 30 patients (94%). 2.Presumed causative organisms were isolated in...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1982/02/25, Vol.35(2), pp.375-393
Main Authors: SUETSUGU, SUSUMU, NAITO, TATSUO, ISHIKAWA, HEIHACHI, UMEDA, HIROMICHI, SUZUKI, KIYOCHIKA, MORISE, MASANORI, SAKAI, SHUZO, SHIMOKATA, KAORU, KATAYAMA, TERUO, KOBAYASHI, TAKASHI, TSUNEKAWA, HIROSHI, NISHIMURA, MINORU, IWAKURA, MITSURU, NISHIWAKI, KEISUKE, NOMURA, YASUO, YOSHIKAWA, KOSHO, FUJI, KOH, IZUMI, SEIYA, KATOH, TOSHIKATSU, ITO, TAKASHI, HATTORI, JIROJI, YOSHII, SATII, TAKEURA, SHIGEKI, MAEDA, Patio
Format: Article
Language:Japanese
Subjects:
Adolescent
Adult
Age Factors
Aged
Cefoxitin - administration & dosage
Cefoxitin - adverse effects
Cefoxitin - therapeutic use
Drug Evaluation
Female
Humans
Infusions, Parenteral
Injections, Intravenous
Male
Middle Aged
Respiratory Tract Infections - drug therapy
Respiratory Tract Infections - microbiology
Sex Factors
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Summary:A total of 42 patients who were suffering from respiratory tract infections were treated with cefoxitin, and the following results were obtained. 1.Out of 32 patients clinically evaluated, excellent or good responses were observed in 30 patients (94%). 2.Presumed causative organisms were isolated in 14 patients.The organisms were eradicated in 11 patients and the eradication rate was 79% (11/14).The number of the organisms decreased or unchanged in 1 patient each.In other 1 patient the pathogenic agent was replaced with other agents during the course of treatment. 3.As for the side effects, skin eruption was observed in 3 patients.One patient received drugs other than cefoxitin concomitantly that might have caused the eruption.Another patient had an allergic history to many antibiotics.In 4 patients slight elevations of S-GOT and S-OPT were observed but improved soon after the completion of cefoxitin treatment.In 1 patient an elevation of serum creatinine was observed but this was not attributed to the administration of cefoxitin. 4.From the results stated above, cefoxitin is considered to be a safe and effective antibiotic which can be one of the first-choice antibiotics for the treatment of respiratory tract infections.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.35.375