Epidemiology and Genetics of Endemic Goiter: II. Genetic Aspects

Complex genetic models and segregation analysis were applied to family data obtained in a hyperendemic goiter area in Brazil. The single locus and Falconer's models did not fit the data. Edward's model showed convergency, but statistical concordance has not been obtained. Although the gene...

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Bibliographic Details
Published in:Human heredity 1982-01, Vol.32 (3), p.176-180
Main Authors: Freire-Maia, Ademar, Freire-Maia, Dértia Villalba
Format: Article
Language:English
Subjects:
Brazil
Chromosome Mapping
Environment
Female
Genetics, Population
Goiter, Endemic - epidemiology
Goiter, Endemic - genetics
Humans
Male
Models, Genetic
Original Papers
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Summary:Complex genetic models and segregation analysis were applied to family data obtained in a hyperendemic goiter area in Brazil. The single locus and Falconer's models did not fit the data. Edward's model showed convergency, but statistical concordance has not been obtained. Although the genetic load model explains statistically the family data, it would be hard to imagine that endemic goiter could be explained by a model where synergism among genetic and environmental factors is net assumed.
ISSN:0001-5652
1423-0062
DOI:10.1159/000153286