Modification of drug-induced catatonia and tremors by quapazine in rats and mice

Administration of perphenazine, tremorine, nicotine and harmine induced Parkinson-like symptoms in rats and mice. The efficacy of quipazine, a serotonin agonist, in antagonizing these drug-induced Parkinsonian symptoms was assessed. Combinations of this drug with other antiparkinsonian agents such a...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1980-04, Vol.30 (2), p.129
Main Authors: Kulkarni, S K, Arzi, A, Kaul, P N
Format: Article
Language:English
Subjects:
Animals
Antiparkinson Agents - pharmacology
Catatonia - chemically induced
Drug Combinations
Drug Interactions
Harmine - pharmacology
Humans
Male
Mice
Nicotine - antagonists & inhibitors
Perphenazine - antagonists & inhibitors
Quinolines - pharmacology
Quipazine - pharmacology
Rats
Tremor - chemically induced
Tremorine - antagonists & inhibitors
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Summary:Administration of perphenazine, tremorine, nicotine and harmine induced Parkinson-like symptoms in rats and mice. The efficacy of quipazine, a serotonin agonist, in antagonizing these drug-induced Parkinsonian symptoms was assessed. Combinations of this drug with other antiparkinsonian agents such as scopolamine, diphenhydramine and amantadine were also studied in the manifestation of Parkinson-like symptoms in the animal models. The results indicate that quipazine, a central serotonergic agent, counteracted some of the drug-induced symptoms of pseudoparkinsonism in laboratory animals. Cholinergic, dopaminergic and histaminergic receptors play an important role in the manifestations of these symptoms.
ISSN:0021-5198