A comparative electron microscope study of early changes in rat liver induced by N-nitrosopiperidine and 2,2',6,6'-tetramethyl-N-nitrosopiperidine

Inbred male Leeds rats were administered either the liver carcinogen N-nitrosopiperidine or the non-carcinogen 2,2',6,6'-tetramethyl-N-nitrosopiperidine in their drinking water at a concentration of 0.02%. Treatment was continued until the animals were killed, at 12 or 28 days, when their...

Full description

Saved in:
Bibliographic Details
Published in:Carcinogenesis (New York) 1981, Vol.2 (5), p.385
Main Authors: Flaks, B, Challis, B C
Format: Article
Language:English
Subjects:
Animals
Carcinogens - pharmacology
Liver - drug effects
Liver - ultrastructure
Male
Microscopy, Electron
Nitrosamines - pharmacology
Piperidines - pharmacology
Rats
Rats, Inbred Strains
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Inbred male Leeds rats were administered either the liver carcinogen N-nitrosopiperidine or the non-carcinogen 2,2',6,6'-tetramethyl-N-nitrosopiperidine in their drinking water at a concentration of 0.02%. Treatment was continued until the animals were killed, at 12 or 28 days, when their hepatic tissues were removed and examined by electron microscopy. Both compounds induced glycogen depletion, cytoplasmic fat accumulation and proliferation of the smooth endoplasmic (ER). In addition, NPIP induced mitochondrial and bile canalicular changes and marked reduction and alteration of the rough ER. The probable relationships of the observed fine structural changes to the metabolism, toxicity and carcinogenicity of these heterocyclic N-nitrosamines are discussed.
ISSN:0143-3334
DOI:10.1093/carcin/2.5.385