Adjuvant chemotherapy of human colorectal adenocarcinoma after growth on mice with congenital thymic dysplasia ("nude"). 1. Experiments to test the feasibility of combined chemotherapy with VCR and 5-FU (author's transl)

• Published in: Journal of cancer research and clinical oncology 1980, Vol.96 (3), p.269
• Main Authors: Schmitz, R, Schmitz, C A, Echtermeyer, V, Pichlmayr, R
• Format: Article
• Language: ger
• Subjects: Adenocarcinoma - drug therapy; Animals; Colonic Neoplasms - drug therapy; Drug Therapy, Combination; Female; Fluorouracil - administration & dosage; Fluorouracil - adverse effects; Fluorouracil - therapeutic use; Mice; Mice, Nude; Neoplasms, Experimental - drug therapy; Rectal Neoplasms - drug therapy; Vincristine - administration & dosage; Vincristine - adverse effects; Vincristine - therapeutic use
• ISSN: 0171-5216
• DOI: 10.1007/BF00408099

Five-week-old syngeneic, female BALB/c nude mice were injected i.p. with vincristine (VCR) and 5-fluorouracil (5-FU) to determine the LD 20 of these drugs under spf-conditions. One hundred fifty animals were given dosages similar to those administered clinically, and a complete autopsy was performed on all nude mice. Whereas VCR caused splenic atrophy and regressive changes in the jejunal epithelium, the application of 5-FU was followed mainly by regressive changes in the transitional epithelium of the bladder, and 67% of the animals developed pneumonia. These pathohistological changes were also seen after a combined chemotherapy, and a temporary leucopenia was reversible. These experiments showed that chemotherapy of nude mice with VCR and 5-FU is possible provided they have been successfully xenotransplanted with human colorectal adenocarcinomas.