Failure of pure 1-naphthylamine to induce bladder tumors in dogs

1-Naphthylamine was administered p.o. to beagles for approximately 9 years at a daily dose of 15 mg/kg (5 days a week). At autopsy, no tumors or other pathological changes were observed in the bladders of any of these animals. With the possible exception of the excessive accumulation of lipofuscin i...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1980-10, Vol.40 (10), p.3537
Main Authors: Radomski, J L, Deichmann, W B, Altman, N H, Radomski, T
Format: Article
Language:English
Subjects:
1-Naphthylamine - metabolism
1-Naphthylamine - toxicity
1-Naphthylamine - urine
Animals
Body Weight
Dogs
Female
Liver - pathology
Male
Naphthalenes - toxicity
Precancerous Conditions - chemically induced
Precancerous Conditions - pathology
Spleen - pathology
Time Factors
Urinary Bladder - pathology
Urinary Bladder Neoplasms - chemically induced
Urinary Bladder Neoplasms - pathology
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Summary:1-Naphthylamine was administered p.o. to beagles for approximately 9 years at a daily dose of 15 mg/kg (5 days a week). At autopsy, no tumors or other pathological changes were observed in the bladders of any of these animals. With the possible exception of the excessive accumulation of lipofuscin in the hepatocytes of these dogs, no test compound-related pathological changes in other tissues of the body were observed. Analysis of the urine revealed the presence of small amounts of N-oxidation products (1-nitrosonaphthalene plus N-hydroxy-1-naphthylamine), ranging from 2.85 to 125 microgram, following a dose of 1-naphthylamine. The theoretical significance of these findings is discussed.
ISSN:0008-5472