Sulfatide, a specific sugar ligand for L-selectin, blocks CCl4-induced liver inflammation in rats

The effects of sulfatide, which is a specific sugar ligand for L-selectin (LECAM-1), on CCl4-induced liver inflammation was studied in rats. Intramuscular pretreatment with sulfatide suppressed the levels of serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) that w...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1995, Vol.59 (1), p.155-157
Main Authors: KAJIHARA, J.-I, YE GUOJI, KATO, K, SUZUKI, Y
Format: Article
Language:English
Subjects:
Alanine Transaminase - blood
Animals
Aspartate Aminotransferases - blood
Biological and medical sciences
Carbon Tetrachloride - toxicity
Cell Adhesion
Cell Adhesion Molecules - metabolism
Chemical and Drug Induced Liver Injury - drug therapy
Chemical and Drug Induced Liver Injury - prevention & control
Female
Fundamental and applied biological sciences. Psychology
Galactosylceramides - pharmacology
Injections, Intramuscular
L-Selectin
Ligands
Liver - drug effects
Liver - pathology
Liver. Bile. Biliary tracts
Membrane Glycoproteins - metabolism
Rats
Rats, Wistar
Receptors, Lymphocyte Homing - metabolism
Sulfoglycosphingolipids - administration & dosage
Sulfoglycosphingolipids - metabolism
Sulfoglycosphingolipids - pharmacology
Vertebrates: digestive system
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Summary:The effects of sulfatide, which is a specific sugar ligand for L-selectin (LECAM-1), on CCl4-induced liver inflammation was studied in rats. Intramuscular pretreatment with sulfatide suppressed the levels of serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) that were increased by CCl4 injection, but galactosylceramide, a desulfated form of sulfatide, did not. A light-microscopic analysis found that the extent and the severity of lesions of the liver cells induced by CCl4 injection were significantly less in the rats treated with sulfatide. These results show that sulfatide suppresses the CCl4-induced liver inflammation by inhibiting the attachment of L-selectin expressing lymphocytes to their native sugar ligands.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.59.155