Alpha/Beta Interferon Is a Neuronal Growth Factor

We investigated the effect of alpha/beta interferon on neuronal survivability. E16 murine telencephalic vesicles were dissected aseptically and grown on collagen-coated coverslips. After 2 weeks of culturing, the media was supplemented with mouse alpha/beta interferon (1,500 U/ml). After an addition...

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Bibliographic Details
Published in:Neuroimmunomodulation 1995-01, Vol.2 (1), p.31-35
Main Authors: Plioplys, Audrius V., Massimini, Nicolas
Format: Article
Language:English
Subjects:
Animals
Cell Count - drug effects
Cell Division - drug effects
Cell Survival - drug effects
Cells, Cultured
Female
Interferon-alpha - pharmacology
Interferon-beta - pharmacology
Mice
Nerve Growth Factors - pharmacology
Neurons - drug effects
Original Paper
Time Factors
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Summary:We investigated the effect of alpha/beta interferon on neuronal survivability. E16 murine telencephalic vesicles were dissected aseptically and grown on collagen-coated coverslips. After 2 weeks of culturing, the media was supplemented with mouse alpha/beta interferon (1,500 U/ml). After an additional 2 weeks of culturing, all of the control cultures demonstrated significant neuronal death. In the 16 interferon-treated cultures, neuronal death took place only in 1 culture, baseline survivability occurred in 2 and proliferation in 13 cultures (p < 0.005). Thus, alpha/beta interferon sustains neuronal growth.
ISSN:1021-7401
1423-0216
DOI:10.1159/000096838