Both neurotoxin II from venom of Naja naja oxiana and its endogenous analogue induce apoptosis in tumor cells

Both neurotoxin II (NT II from venom of Naja naja oxiana) and 20-30 kDa proteins partially purified from pig brain (NTlm) cross-reacting with antibodies to NT II were cytotoxic for L929 and K562 tumor cells at concentrations of 10(-6)-10(-8) M. Modification of Cys residues significantly reduced cyto...

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Bibliographic Details
Published in:FEBS letters 1994-02, Vol.340 (1-2), p.22
Main Authors: Strizhkov, B N, Blishchenko EYu, Satpaev, D K, Karelin, A A
Format: Article
Language:English
Subjects:
Animals
Apoptosis - drug effects
Cobra Neurotoxin Proteins - chemistry
Cobra Neurotoxin Proteins - toxicity
Cystine - chemistry
Nerve Tissue Proteins - pharmacology
Swine
Tumor Cells, Cultured
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Summary:Both neurotoxin II (NT II from venom of Naja naja oxiana) and 20-30 kDa proteins partially purified from pig brain (NTlm) cross-reacting with antibodies to NT II were cytotoxic for L929 and K562 tumor cells at concentrations of 10(-6)-10(-8) M. Modification of Cys residues significantly reduced cytotoxicity of NT II. Both NT2 and NTlm induced apoptosis in L929 and K562 cells.
ISSN:0014-5793