Ninety day toxicity of carbaryl in male rats

Oral administration of carbaryl (200 mg/kg for 3 days a week) for a period of 90 days did not produce any overt toxicological signs in male rats. There were no significant histological changes in testes, epididymis, liver and kidney. Similarly, no marked biochemical changes were seen in testes, live...

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Bibliographic Details
Published in:Environmental research 1976-10, Vol.12 (2), p.161-170
Main Authors: Dikshith, T.S.S., Gupta, P.K., Gaur, J.S., Datta, K.K., Mathur, Anil K.
Format: Article
Language:English
Subjects:
Acetylcholinesterase - blood
Administration, Oral
Animals
Brain - anatomy & histology
Carbaryl - administration & dosage
Carbaryl - toxicity
Epididymis - anatomy & histology
Kidney - anatomy & histology
Liver - anatomy & histology
Male
Rats
Testis - analysis
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Summary:Oral administration of carbaryl (200 mg/kg for 3 days a week) for a period of 90 days did not produce any overt toxicological signs in male rats. There were no significant histological changes in testes, epididymis, liver and kidney. Similarly, no marked biochemical changes were seen in testes, liver, and brain. The activity of acetylcholine esterase in blood of carbaryl treated rats was, however, found to be decreased. Carbaryl did not affect the fertility of male rats at 200 mg/kg up to 90 days.
ISSN:0013-9351
1096-0953
DOI:10.1016/0013-9351(76)90019-0