CLINICAL EFFECTS OF A COMBINATION TREATMENT WITH CEFODIZIME AND MINOCYCLINE FOR INFECTIONS IN PATIENTS COMPLICATED WITH HEMATOLOGICAL DISORDERS

We evaluated clinical effects and toxicities of a combination in treatment with cefodizime (CDZM) and minocycline (MINO) for infections complicated with hematological disorders in 67 patients. Fifty-nine patients were evaluable, including 32 with acute leukemia, 15 with malignant lymphoma, and 12 wi...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1993/08/25, Vol.46(8), pp.686-696
Main Authors: HIRAKAWA, KOUICHI, TSUDA, SHOICHIRO, MISAWA, SHINICHI, KUZUYAMA, YUKO, NAKAI, HIROYUKI, SERIU, TAKU, TAKASHIMA, TERUYUKI, TANAKA, SHINJI, NISHIGAKI, HIKARI, YOKOTA, SHOUHEI, HORIIKE, SHIGEO, TANIWAKI, MASAFUMI, KASHIMA, KEI, NAKAGAWA, HITOSHI, FUJII, HIROSHI, NAKAI, TETSURO, OHKAWARA, YASUO
Format: Article
Language:Japanese
Subjects:
Adult
Aged
Aged, 80 and over
Alanine Transaminase
Aspartate Aminotransferases
Bacterial Infections - drug therapy
Bacterial Infections - etiology
Bacterial Infections - microbiology
Cefotaxime - adverse effects
Cefotaxime - analogs & derivatives
Cefotaxime - therapeutic use
Drug Evaluation
Drug Therapy, Combination - adverse effects
Drug Therapy, Combination - therapeutic use
Female
Hematologic Diseases - complications
Humans
Immunocompromised Host
Male
Middle Aged
Minocycline - adverse effects
Minocycline - therapeutic use
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Summary:We evaluated clinical effects and toxicities of a combination in treatment with cefodizime (CDZM) and minocycline (MINO) for infections complicated with hematological disorders in 67 patients. Fifty-nine patients were evaluable, including 32 with acute leukemia, 15 with malignant lymphoma, and 12 with other hematological disorders. Clinical efficacies were excellent in 17 cases, good in 24 cases, fair in 2 cases, and poor in 16 cases. The efficacy rate was 69.5% (41 cases/59 cases). This treatment was also effective in 8 of 12 cases in which granulocyte counts were less than 500/μl through the course of administration. No subjective side effects were observed. Abnormal values in laboratory tests were noted in 5 cases. Mild elevations of GOT, GPT, Al-P and bilirubin were observed, but none was serious. Thus, the combination of CDZM and MINO is an effective and safe regimen for the treatment of infections in patients complicated with hematological disorders.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.46.686