Loading…
CLINICAL EFFECTS OF A COMBINATION TREATMENT WITH CEFODIZIME AND MINOCYCLINE FOR INFECTIONS IN PATIENTS COMPLICATED WITH HEMATOLOGICAL DISORDERS
We evaluated clinical effects and toxicities of a combination in treatment with cefodizime (CDZM) and minocycline (MINO) for infections complicated with hematological disorders in 67 patients. Fifty-nine patients were evaluable, including 32 with acute leukemia, 15 with malignant lymphoma, and 12 wi...
Saved in:
| Published in: | Japanese journal of antibiotics 1993/08/25, Vol.46(8), pp.686-696 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | Japanese |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | |
| container_end_page | 696 |
| container_issue | 8 |
| container_start_page | 686 |
| container_title | Japanese journal of antibiotics |
| container_volume | 46 |
| creator | HIRAKAWA, KOUICHI TSUDA, SHOICHIRO MISAWA, SHINICHI KUZUYAMA, YUKO NAKAI, HIROYUKI SERIU, TAKU TAKASHIMA, TERUYUKI TANAKA, SHINJI NISHIGAKI, HIKARI YOKOTA, SHOUHEI HORIIKE, SHIGEO TANIWAKI, MASAFUMI KASHIMA, KEI NAKAGAWA, HITOSHI FUJII, HIROSHI NAKAI, TETSURO OHKAWARA, YASUO |
| description | We evaluated clinical effects and toxicities of a combination in treatment with cefodizime (CDZM) and minocycline (MINO) for infections complicated with hematological disorders in 67 patients. Fifty-nine patients were evaluable, including 32 with acute leukemia, 15 with malignant lymphoma, and 12 with other hematological disorders. Clinical efficacies were excellent in 17 cases, good in 24 cases, fair in 2 cases, and poor in 16 cases. The efficacy rate was 69.5% (41 cases/59 cases). This treatment was also effective in 8 of 12 cases in which granulocyte counts were less than 500/μl through the course of administration. No subjective side effects were observed. Abnormal values in laboratory tests were noted in 5 cases. Mild elevations of GOT, GPT, Al-P and bilirubin were observed, but none was serious. Thus, the combination of CDZM and MINO is an effective and safe regimen for the treatment of infections in patients complicated with hematological disorders. |
| doi_str_mv | 10.11553/antibiotics1968b.46.686 |
| format | article |
| fullrecord | <record><control><sourceid>pubmed_jstag</sourceid><recordid>TN_cdi_pubmed_primary_8230736</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>8230736</sourcerecordid><originalsourceid>FETCH-LOGICAL-j1206-83ece4b1c17607fe162548b68cf463945a6c6bb0b74b6cc912ee011c9713294c3</originalsourceid><addsrcrecordid>eNpdkcFOhDAQhhuj0Y36CCZ9AVZKS1uOCMWtAWqgxuiF0NpVzK4aWA8-ha9s19148DIzyT__9yczAEAUzhGKY3zZv20GM7xvBjuhhHIzJ3ROOT0AswhxGsSEsUMwCzHlQcQ4OgHn0zSYECPGI084Bsc8wiHDdAa-s1LWMktLKIpCZLqFqoApzFR1JetUS1VD3YhUV6LW8F7qBcxEoXL5KCsB0zqHlaxV9rClCFioBsp6i_G-1o_w1iO8s90Cb0ufo0W-wyxElWpVquvf8Fy2qslF056Bo2W_mtz5vp-Cu0LobBHsN4NXFIU04NhZRwyyiNGQLR2iUUy4odwuCcUJiXtqqTGhYcRQaxMUORciZBOGcJQQi0_BxY778WnW7qn7GId1P351-8N4_Wanv06b_tn96f3or75y3f8XdIR2fFv8H_6W7Es_du4N_wDoR3ki</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>CLINICAL EFFECTS OF A COMBINATION TREATMENT WITH CEFODIZIME AND MINOCYCLINE FOR INFECTIONS IN PATIENTS COMPLICATED WITH HEMATOLOGICAL DISORDERS</title><source>Alma/SFX Local Collection</source><creator>HIRAKAWA, KOUICHI ; TSUDA, SHOICHIRO ; MISAWA, SHINICHI ; KUZUYAMA, YUKO ; NAKAI, HIROYUKI ; SERIU, TAKU ; TAKASHIMA, TERUYUKI ; TANAKA, SHINJI ; NISHIGAKI, HIKARI ; YOKOTA, SHOUHEI ; HORIIKE, SHIGEO ; TANIWAKI, MASAFUMI ; KASHIMA, KEI ; NAKAGAWA, HITOSHI ; FUJII, HIROSHI ; NAKAI, TETSURO ; OHKAWARA, YASUO</creator><creatorcontrib>HIRAKAWA, KOUICHI ; TSUDA, SHOICHIRO ; MISAWA, SHINICHI ; KUZUYAMA, YUKO ; NAKAI, HIROYUKI ; SERIU, TAKU ; TAKASHIMA, TERUYUKI ; TANAKA, SHINJI ; NISHIGAKI, HIKARI ; YOKOTA, SHOUHEI ; HORIIKE, SHIGEO ; TANIWAKI, MASAFUMI ; KASHIMA, KEI ; NAKAGAWA, HITOSHI ; FUJII, HIROSHI ; NAKAI, TETSURO ; OHKAWARA, YASUO</creatorcontrib><description>We evaluated clinical effects and toxicities of a combination in treatment with cefodizime (CDZM) and minocycline (MINO) for infections complicated with hematological disorders in 67 patients. Fifty-nine patients were evaluable, including 32 with acute leukemia, 15 with malignant lymphoma, and 12 with other hematological disorders. Clinical efficacies were excellent in 17 cases, good in 24 cases, fair in 2 cases, and poor in 16 cases. The efficacy rate was 69.5% (41 cases/59 cases). This treatment was also effective in 8 of 12 cases in which granulocyte counts were less than 500/μl through the course of administration. No subjective side effects were observed. Abnormal values in laboratory tests were noted in 5 cases. Mild elevations of GOT, GPT, Al-P and bilirubin were observed, but none was serious. Thus, the combination of CDZM and MINO is an effective and safe regimen for the treatment of infections in patients complicated with hematological disorders.</description><identifier>ISSN: 0368-2781</identifier><identifier>EISSN: 2186-5477</identifier><identifier>DOI: 10.11553/antibiotics1968b.46.686</identifier><identifier>PMID: 8230736</identifier><language>jpn</language><publisher>Japan: Japan Antibiotics Research Association</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alanine Transaminase ; Aspartate Aminotransferases ; Bacterial Infections - drug therapy ; Bacterial Infections - etiology ; Bacterial Infections - microbiology ; Cefotaxime - adverse effects ; Cefotaxime - analogs & derivatives ; Cefotaxime - therapeutic use ; Drug Evaluation ; Drug Therapy, Combination - adverse effects ; Drug Therapy, Combination - therapeutic use ; Female ; Hematologic Diseases - complications ; Humans ; Immunocompromised Host ; Male ; Middle Aged ; Minocycline - adverse effects ; Minocycline - therapeutic use</subject><ispartof>The Japanese Journal of Antibiotics, 1993/08/25, Vol.46(8), pp.686-696</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8230736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HIRAKAWA, KOUICHI</creatorcontrib><creatorcontrib>TSUDA, SHOICHIRO</creatorcontrib><creatorcontrib>MISAWA, SHINICHI</creatorcontrib><creatorcontrib>KUZUYAMA, YUKO</creatorcontrib><creatorcontrib>NAKAI, HIROYUKI</creatorcontrib><creatorcontrib>SERIU, TAKU</creatorcontrib><creatorcontrib>TAKASHIMA, TERUYUKI</creatorcontrib><creatorcontrib>TANAKA, SHINJI</creatorcontrib><creatorcontrib>NISHIGAKI, HIKARI</creatorcontrib><creatorcontrib>YOKOTA, SHOUHEI</creatorcontrib><creatorcontrib>HORIIKE, SHIGEO</creatorcontrib><creatorcontrib>TANIWAKI, MASAFUMI</creatorcontrib><creatorcontrib>KASHIMA, KEI</creatorcontrib><creatorcontrib>NAKAGAWA, HITOSHI</creatorcontrib><creatorcontrib>FUJII, HIROSHI</creatorcontrib><creatorcontrib>NAKAI, TETSURO</creatorcontrib><creatorcontrib>OHKAWARA, YASUO</creatorcontrib><title>CLINICAL EFFECTS OF A COMBINATION TREATMENT WITH CEFODIZIME AND MINOCYCLINE FOR INFECTIONS IN PATIENTS COMPLICATED WITH HEMATOLOGICAL DISORDERS</title><title>Japanese journal of antibiotics</title><addtitle>Jpn. J. Antibiotics</addtitle><description>We evaluated clinical effects and toxicities of a combination in treatment with cefodizime (CDZM) and minocycline (MINO) for infections complicated with hematological disorders in 67 patients. Fifty-nine patients were evaluable, including 32 with acute leukemia, 15 with malignant lymphoma, and 12 with other hematological disorders. Clinical efficacies were excellent in 17 cases, good in 24 cases, fair in 2 cases, and poor in 16 cases. The efficacy rate was 69.5% (41 cases/59 cases). This treatment was also effective in 8 of 12 cases in which granulocyte counts were less than 500/μl through the course of administration. No subjective side effects were observed. Abnormal values in laboratory tests were noted in 5 cases. Mild elevations of GOT, GPT, Al-P and bilirubin were observed, but none was serious. Thus, the combination of CDZM and MINO is an effective and safe regimen for the treatment of infections in patients complicated with hematological disorders.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alanine Transaminase</subject><subject>Aspartate Aminotransferases</subject><subject>Bacterial Infections - drug therapy</subject><subject>Bacterial Infections - etiology</subject><subject>Bacterial Infections - microbiology</subject><subject>Cefotaxime - adverse effects</subject><subject>Cefotaxime - analogs & derivatives</subject><subject>Cefotaxime - therapeutic use</subject><subject>Drug Evaluation</subject><subject>Drug Therapy, Combination - adverse effects</subject><subject>Drug Therapy, Combination - therapeutic use</subject><subject>Female</subject><subject>Hematologic Diseases - complications</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Minocycline - adverse effects</subject><subject>Minocycline - therapeutic use</subject><issn>0368-2781</issn><issn>2186-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNpdkcFOhDAQhhuj0Y36CCZ9AVZKS1uOCMWtAWqgxuiF0NpVzK4aWA8-ha9s19148DIzyT__9yczAEAUzhGKY3zZv20GM7xvBjuhhHIzJ3ROOT0AswhxGsSEsUMwCzHlQcQ4OgHn0zSYECPGI084Bsc8wiHDdAa-s1LWMktLKIpCZLqFqoApzFR1JetUS1VD3YhUV6LW8F7qBcxEoXL5KCsB0zqHlaxV9rClCFioBsp6i_G-1o_w1iO8s90Cb0ufo0W-wyxElWpVquvf8Fy2qslF056Bo2W_mtz5vp-Cu0LobBHsN4NXFIU04NhZRwyyiNGQLR2iUUy4odwuCcUJiXtqqTGhYcRQaxMUORciZBOGcJQQi0_BxY778WnW7qn7GId1P351-8N4_Wanv06b_tn96f3or75y3f8XdIR2fFv8H_6W7Es_du4N_wDoR3ki</recordid><startdate>199308</startdate><enddate>199308</enddate><creator>HIRAKAWA, KOUICHI</creator><creator>TSUDA, SHOICHIRO</creator><creator>MISAWA, SHINICHI</creator><creator>KUZUYAMA, YUKO</creator><creator>NAKAI, HIROYUKI</creator><creator>SERIU, TAKU</creator><creator>TAKASHIMA, TERUYUKI</creator><creator>TANAKA, SHINJI</creator><creator>NISHIGAKI, HIKARI</creator><creator>YOKOTA, SHOUHEI</creator><creator>HORIIKE, SHIGEO</creator><creator>TANIWAKI, MASAFUMI</creator><creator>KASHIMA, KEI</creator><creator>NAKAGAWA, HITOSHI</creator><creator>FUJII, HIROSHI</creator><creator>NAKAI, TETSURO</creator><creator>OHKAWARA, YASUO</creator><general>Japan Antibiotics Research Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>199308</creationdate><title>CLINICAL EFFECTS OF A COMBINATION TREATMENT WITH CEFODIZIME AND MINOCYCLINE FOR INFECTIONS IN PATIENTS COMPLICATED WITH HEMATOLOGICAL DISORDERS</title><author>HIRAKAWA, KOUICHI ; TSUDA, SHOICHIRO ; MISAWA, SHINICHI ; KUZUYAMA, YUKO ; NAKAI, HIROYUKI ; SERIU, TAKU ; TAKASHIMA, TERUYUKI ; TANAKA, SHINJI ; NISHIGAKI, HIKARI ; YOKOTA, SHOUHEI ; HORIIKE, SHIGEO ; TANIWAKI, MASAFUMI ; KASHIMA, KEI ; NAKAGAWA, HITOSHI ; FUJII, HIROSHI ; NAKAI, TETSURO ; OHKAWARA, YASUO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j1206-83ece4b1c17607fe162548b68cf463945a6c6bb0b74b6cc912ee011c9713294c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alanine Transaminase</topic><topic>Aspartate Aminotransferases</topic><topic>Bacterial Infections - drug therapy</topic><topic>Bacterial Infections - etiology</topic><topic>Bacterial Infections - microbiology</topic><topic>Cefotaxime - adverse effects</topic><topic>Cefotaxime - analogs & derivatives</topic><topic>Cefotaxime - therapeutic use</topic><topic>Drug Evaluation</topic><topic>Drug Therapy, Combination - adverse effects</topic><topic>Drug Therapy, Combination - therapeutic use</topic><topic>Female</topic><topic>Hematologic Diseases - complications</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Minocycline - adverse effects</topic><topic>Minocycline - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HIRAKAWA, KOUICHI</creatorcontrib><creatorcontrib>TSUDA, SHOICHIRO</creatorcontrib><creatorcontrib>MISAWA, SHINICHI</creatorcontrib><creatorcontrib>KUZUYAMA, YUKO</creatorcontrib><creatorcontrib>NAKAI, HIROYUKI</creatorcontrib><creatorcontrib>SERIU, TAKU</creatorcontrib><creatorcontrib>TAKASHIMA, TERUYUKI</creatorcontrib><creatorcontrib>TANAKA, SHINJI</creatorcontrib><creatorcontrib>NISHIGAKI, HIKARI</creatorcontrib><creatorcontrib>YOKOTA, SHOUHEI</creatorcontrib><creatorcontrib>HORIIKE, SHIGEO</creatorcontrib><creatorcontrib>TANIWAKI, MASAFUMI</creatorcontrib><creatorcontrib>KASHIMA, KEI</creatorcontrib><creatorcontrib>NAKAGAWA, HITOSHI</creatorcontrib><creatorcontrib>FUJII, HIROSHI</creatorcontrib><creatorcontrib>NAKAI, TETSURO</creatorcontrib><creatorcontrib>OHKAWARA, YASUO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Japanese journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HIRAKAWA, KOUICHI</au><au>TSUDA, SHOICHIRO</au><au>MISAWA, SHINICHI</au><au>KUZUYAMA, YUKO</au><au>NAKAI, HIROYUKI</au><au>SERIU, TAKU</au><au>TAKASHIMA, TERUYUKI</au><au>TANAKA, SHINJI</au><au>NISHIGAKI, HIKARI</au><au>YOKOTA, SHOUHEI</au><au>HORIIKE, SHIGEO</au><au>TANIWAKI, MASAFUMI</au><au>KASHIMA, KEI</au><au>NAKAGAWA, HITOSHI</au><au>FUJII, HIROSHI</au><au>NAKAI, TETSURO</au><au>OHKAWARA, YASUO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CLINICAL EFFECTS OF A COMBINATION TREATMENT WITH CEFODIZIME AND MINOCYCLINE FOR INFECTIONS IN PATIENTS COMPLICATED WITH HEMATOLOGICAL DISORDERS</atitle><jtitle>Japanese journal of antibiotics</jtitle><addtitle>Jpn. J. Antibiotics</addtitle><date>1993-08</date><risdate>1993</risdate><volume>46</volume><issue>8</issue><spage>686</spage><epage>696</epage><pages>686-696</pages><issn>0368-2781</issn><eissn>2186-5477</eissn><abstract>We evaluated clinical effects and toxicities of a combination in treatment with cefodizime (CDZM) and minocycline (MINO) for infections complicated with hematological disorders in 67 patients. Fifty-nine patients were evaluable, including 32 with acute leukemia, 15 with malignant lymphoma, and 12 with other hematological disorders. Clinical efficacies were excellent in 17 cases, good in 24 cases, fair in 2 cases, and poor in 16 cases. The efficacy rate was 69.5% (41 cases/59 cases). This treatment was also effective in 8 of 12 cases in which granulocyte counts were less than 500/μl through the course of administration. No subjective side effects were observed. Abnormal values in laboratory tests were noted in 5 cases. Mild elevations of GOT, GPT, Al-P and bilirubin were observed, but none was serious. Thus, the combination of CDZM and MINO is an effective and safe regimen for the treatment of infections in patients complicated with hematological disorders.</abstract><cop>Japan</cop><pub>Japan Antibiotics Research Association</pub><pmid>8230736</pmid><doi>10.11553/antibiotics1968b.46.686</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0368-2781 |
| ispartof | The Japanese Journal of Antibiotics, 1993/08/25, Vol.46(8), pp.686-696 |
| issn | 0368-2781 2186-5477 |
| language | jpn |
| recordid | cdi_pubmed_primary_8230736 |
| source | Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Alanine Transaminase Aspartate Aminotransferases Bacterial Infections - drug therapy Bacterial Infections - etiology Bacterial Infections - microbiology Cefotaxime - adverse effects Cefotaxime - analogs & derivatives Cefotaxime - therapeutic use Drug Evaluation Drug Therapy, Combination - adverse effects Drug Therapy, Combination - therapeutic use Female Hematologic Diseases - complications Humans Immunocompromised Host Male Middle Aged Minocycline - adverse effects Minocycline - therapeutic use |
| title | CLINICAL EFFECTS OF A COMBINATION TREATMENT WITH CEFODIZIME AND MINOCYCLINE FOR INFECTIONS IN PATIENTS COMPLICATED WITH HEMATOLOGICAL DISORDERS |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T01%3A09%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_jstag&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CLINICAL%20EFFECTS%20OF%20A%20COMBINATION%20TREATMENT%20WITH%20CEFODIZIME%20AND%20MINOCYCLINE%20FOR%20INFECTIONS%20IN%20PATIENTS%20COMPLICATED%20WITH%20HEMATOLOGICAL%20DISORDERS&rft.jtitle=Japanese%20journal%20of%20antibiotics&rft.au=HIRAKAWA,%20KOUICHI&rft.date=1993-08&rft.volume=46&rft.issue=8&rft.spage=686&rft.epage=696&rft.pages=686-696&rft.issn=0368-2781&rft.eissn=2186-5477&rft_id=info:doi/10.11553/antibiotics1968b.46.686&rft_dat=%3Cpubmed_jstag%3E8230736%3C/pubmed_jstag%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-j1206-83ece4b1c17607fe162548b68cf463945a6c6bb0b74b6cc912ee011c9713294c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/8230736&rfr_iscdi=true |