Monitoring the adverse profile of atenolol--a collaborative study

Atenolol, a cardio selective beta-adrenergic blocker, frequently prescribed in various cardiac ailments, has not been thoroughly investigated for its adverse reaction profile in Indian patient. The present ADR monitoring study which was open, prospective and collaborative was therefore planned. A to...

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Bibliographic Details
Published in:Indian journal of physiology and pharmacology 1993-07, Vol.37 (3), p.213
Main Authors: Garg, K C, Singhal, K C, Kumar, S
Format: Article
Language:English
Subjects:
Atenolol - adverse effects
Atenolol - therapeutic use
Cardiovascular Diseases - complications
Cardiovascular Diseases - drug therapy
Humans
Middle Aged
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Summary:Atenolol, a cardio selective beta-adrenergic blocker, frequently prescribed in various cardiac ailments, has not been thoroughly investigated for its adverse reaction profile in Indian patient. The present ADR monitoring study which was open, prospective and collaborative was therefore planned. A total of 440 patients with various heart disease were enrolled after a strict inclusion and exclusion criteria from Maulana Azad Medical College, New Delhi and J.N. Medical College, Aligarh. fifteen patients dropped out leaving 435 for final analysis. Cold extremities occurred in 1.18% headache and dizziness in 1.41% breathlessness in 0.94% oedema in 0.70% and bradycardia in 0.47%. Adverse drug reaction in our study were less than those reported from Western countries. Better patient selection, optimal dose could have reduced the frequency of ADR in the present study. Racial factor and season might be operating to bring down ADR to atenolol in Indian patients.
ISSN:0019-5499