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Neonatal encephalitis caused by herpes simplex: immunohistochemical diagnosis of a case

The authors report the case of a female newborn infant, who had seizures and vesicles at the nose and inferior lip since the fifth day of life. CSF changes suggested an encephalitis. Signs of neurologic and respiratory deterioration were followed by death. Partial cranial autopsy showed a necrohemor...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 1993-09, Vol.51 (3), p.377
Main Authors: Lamego, I, Brinckmann, C, Ciancio, A, Minotto, R, Hilbig, A, Ulbrich-Kulczynski, J M, Fontana, M H, Barbosa-Coutinho, L M
Format: Article
Language:Portuguese
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Summary:The authors report the case of a female newborn infant, who had seizures and vesicles at the nose and inferior lip since the fifth day of life. CSF changes suggested an encephalitis. Signs of neurologic and respiratory deterioration were followed by death. Partial cranial autopsy showed a necrohemorrhagic temporal encephalitis without intranuclear inclusions. Immunohistochemical examination by the avidin-biotin-peroxidase technique with polyclonal antibodies against Herpes simplex type 1 and type 2 was positive to type 2 Herpes simplex virus.
ISSN:0004-282X