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Neonatal encephalitis caused by herpes simplex: immunohistochemical diagnosis of a case

The authors report the case of a female newborn infant, who had seizures and vesicles at the nose and inferior lip since the fifth day of life. CSF changes suggested an encephalitis. Signs of neurologic and respiratory deterioration were followed by death. Partial cranial autopsy showed a necrohemor...

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Published in:Arquivos de neuro-psiquiatria 1993-09, Vol.51 (3), p.377
Main Authors: Lamego, I, Brinckmann, C, Ciancio, A, Minotto, R, Hilbig, A, Ulbrich-Kulczynski, J M, Fontana, M H, Barbosa-Coutinho, L M
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container_title Arquivos de neuro-psiquiatria
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creator Lamego, I
Brinckmann, C
Ciancio, A
Minotto, R
Hilbig, A
Ulbrich-Kulczynski, J M
Fontana, M H
Barbosa-Coutinho, L M
description The authors report the case of a female newborn infant, who had seizures and vesicles at the nose and inferior lip since the fifth day of life. CSF changes suggested an encephalitis. Signs of neurologic and respiratory deterioration were followed by death. Partial cranial autopsy showed a necrohemorrhagic temporal encephalitis without intranuclear inclusions. Immunohistochemical examination by the avidin-biotin-peroxidase technique with polyclonal antibodies against Herpes simplex type 1 and type 2 was positive to type 2 Herpes simplex virus.
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subjects Encephalitis - cerebrospinal fluid
Encephalitis - etiology
Encephalitis - pathology
Female
Herpes Simplex - cerebrospinal fluid
Herpes Simplex - complications
Herpes Simplex - pathology
Humans
Immunohistochemistry
Infant, Newborn
title Neonatal encephalitis caused by herpes simplex: immunohistochemical diagnosis of a case
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