Interactions of Nocardia asteroides with murine glia cells in culture

Astrocytes and microglia were obtained from brains of newborn mice and infected with Nocardia asteroides. Scanning electron micrographs showed nocardiae adhering to the astrocyte cell surface and entering the cytoplasm. After 6 h of incubation the intracellular nocardiae appeared as filaments, demon...

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Bibliographic Details
Published in:Infection and Immunity 1993-01, Vol.61 (1), p.343-347
Main Authors: Beaman, L. (University of California, Davis, CA), Beaman, B.L
Format: Article
Language:English
Subjects:
Animals
Astrocytes - microbiology
Astrocytes - ultrastructure
Biological and medical sciences
Cell Division
Cell interactions, adhesion
Cells, Cultured
Fundamental and applied biological sciences. Psychology
Mice
Microscopy, Electron, Scanning
Molecular and cellular biology
NERF
NERVIOS
Neuroglia - microbiology
Neuroglia - ultrastructure
NOCARDIA
Nocardia asteroides
Nocardia asteroides - cytology
Nocardia Infections - pathology
RATON
SOURIS
TEJIDOS ANIMALES
TISSU ANIMAL
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Summary:Astrocytes and microglia were obtained from brains of newborn mice and infected with Nocardia asteroides. Scanning electron micrographs showed nocardiae adhering to the astrocyte cell surface and entering the cytoplasm. After 6 h of incubation the intracellular nocardiae appeared as filaments, demonstrating that growth was occurring. In contrast, the microglia phagocytized nocardiae, but after 6 h the presence of coccoid cells indicated that nocardial growth was inhibited
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.61.1.343-347.1993