Inorganic fluoride nephrotoxicity: prolonged enflurane and halothane anesthesia in volunteers

The effects of prolonged enflurane and halothane administration on urine-concentrating ability were determined in volunteers by examining their responses to vasopressin before anesthesia and on days 1 and 5 after anesthesia. A significant decrease in maximum urinary osmolality of 264 +/- 34 mOsm/kg...

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Bibliographic Details
Published in:Anesthesiology (Philadelphia) 1977-01, Vol.46 (4), p.265
Main Authors: Mazze, R I, Calverley, R K, Smith, N T
Format: Article
Language:English
Subjects:
Adult
Bromides - blood
Enflurane - pharmacology
Fluorides - blood
Glomerular Filtration Rate - drug effects
Halothane - pharmacology
Humans
Kidney Concentrating Ability - drug effects
Male
Methyl Ethers - pharmacology
Osmolar Concentration
Vasopressins
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Summary:The effects of prolonged enflurane and halothane administration on urine-concentrating ability were determined in volunteers by examining their responses to vasopressin before anesthesia and on days 1 and 5 after anesthesia. A significant decrease in maximum urinary osmolality of 264 +/- 34 mOsm/kg (26 per cent of the preanesthetic value) was present on day 1 after enflurane anesthesia, whereas subjects anesthetized with halothane had a significant increase in maximum urinary osmolality of 120 +/- 44 mOsm/kg. Serum inorganic fluoride level peaked at 33.6 muM and remained above 20 muM for approximately 18 hours. Thus, the threshold level for inorganic fluoride nephrotoxicity is lower than previously suspected.
ISSN:0003-3022
DOI:10.1097/00000542-197704000-00007