Loading…

Comparative nephrotoxic effects of cis-platinum (II), cis-palladium (II), and cis-rhodium (III) metal coordination compounds in rat kidneys

A Sprague-Dawley rat kidney perfusion technique was used in situ to study the effects of cis-dichloro-diamine platinum, PdCl2 (2,6-diaminopyridine), and RhCl3 (2,6-diaminopyridine) on sodium and calcium retention in the whole kidney. The technique involves perfusion of both kidneys via the abdominal...

Full description

Saved in:
Bibliographic Details
Published in:Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology Pharmacology, toxicology & endocrinology, 1995-07, Vol.111 (3), p.423
Main Authors: Bikhazi, A B, Salameh, A, el-Kasti, M M, Awar, R A
Format: Article
Language:English
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue 3
container_start_page 423
container_title Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology
container_volume 111
creator Bikhazi, A B
Salameh, A
el-Kasti, M M
Awar, R A
description A Sprague-Dawley rat kidney perfusion technique was used in situ to study the effects of cis-dichloro-diamine platinum, PdCl2 (2,6-diaminopyridine), and RhCl3 (2,6-diaminopyridine) on sodium and calcium retention in the whole kidney. The technique involves perfusion of both kidneys via the abdominal aorta and then through the right and left renal arteries and dorsal aorta. Compared to controls, kidneys perfused independently with the three coordination compounds showed approximately equal to 45% decrease and approximately equal to 117% increase in Na+ and Ca2+ retention, respectively. Perfusates containing the coordination compounds in addition to 15 mM ouabain showed approximately equal to 76% decrease in Na+ and insignificant increase in renal Ca2+ retention. Hence, one can rule out the presence of voltage-gated Ca(2+)-channels at the basolateral side due to membrane depolarization. These results suggest that the three metal coordination compounds showed identical nephrotoxic effects on the handling of Na+ and Ca2+ ions by inhibiting both the Na(+)-Ca(2+)-anti-porter and the Na(+)-H(+)-exchanger with laxing effects on nonvoltage-gated Ca(2+)-channels at the basolateral side. However, their effects on the Na(+)-K(+)-ATPase and the Na(+)-Ca2+ symporter was insignificant.
format article
fullrecord <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_8564782</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>8564782</sourcerecordid><originalsourceid>FETCH-LOGICAL-p532-7de7c69c7f30d415b9f3c919240e1af6b12d347eece6868f3a8c0f422778bbde3</originalsourceid><addsrcrecordid>eNo9kM1KxDAcxHNQ1nX1EYQcXbCQJm2SHqX4UVjwsvclTf5ho20Skq64z-BLW9zV0zA_hhmYC7QsGReFpJJcoeuc3wkhjIlmgRay5pWQdIm-2zBGldTkPgF7iPsUpvDlNAZrQU8ZB4u1y0Uc5og_jPi-69YPJ6SGQRn3z5Q3vzztwx_t1niESQ1Yh5CM83NH8LMZYzh4k7HzeJ7GH854OOYbdGnVkOH2rCu0fX7atq_F5u2lax83RawZLYQBoXmjhWXEVGXdN5bppmxoRaBUlvclNawSABq45NIyJTWxFaVCyL43wFbo7lQbD_0IZheTG1U67s6fsB8oQF3q</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Comparative nephrotoxic effects of cis-platinum (II), cis-palladium (II), and cis-rhodium (III) metal coordination compounds in rat kidneys</title><source>ScienceDirect Journals</source><creator>Bikhazi, A B ; Salameh, A ; el-Kasti, M M ; Awar, R A</creator><creatorcontrib>Bikhazi, A B ; Salameh, A ; el-Kasti, M M ; Awar, R A</creatorcontrib><description>A Sprague-Dawley rat kidney perfusion technique was used in situ to study the effects of cis-dichloro-diamine platinum, PdCl2 (2,6-diaminopyridine), and RhCl3 (2,6-diaminopyridine) on sodium and calcium retention in the whole kidney. The technique involves perfusion of both kidneys via the abdominal aorta and then through the right and left renal arteries and dorsal aorta. Compared to controls, kidneys perfused independently with the three coordination compounds showed approximately equal to 45% decrease and approximately equal to 117% increase in Na+ and Ca2+ retention, respectively. Perfusates containing the coordination compounds in addition to 15 mM ouabain showed approximately equal to 76% decrease in Na+ and insignificant increase in renal Ca2+ retention. Hence, one can rule out the presence of voltage-gated Ca(2+)-channels at the basolateral side due to membrane depolarization. These results suggest that the three metal coordination compounds showed identical nephrotoxic effects on the handling of Na+ and Ca2+ ions by inhibiting both the Na(+)-Ca(2+)-anti-porter and the Na(+)-H(+)-exchanger with laxing effects on nonvoltage-gated Ca(2+)-channels at the basolateral side. However, their effects on the Na(+)-K(+)-ATPase and the Na(+)-Ca2+ symporter was insignificant.</description><identifier>ISSN: 1367-8280</identifier><identifier>PMID: 8564782</identifier><language>eng</language><publisher>United States</publisher><subject>Analysis of Variance ; Animals ; Antineoplastic Agents - administration &amp; dosage ; Antineoplastic Agents - toxicity ; Calcium - metabolism ; Calcium Channels - drug effects ; Calcium Channels - metabolism ; Cisplatin - administration &amp; dosage ; Cisplatin - toxicity ; Female ; Ouabain - administration &amp; dosage ; Ouabain - pharmacology ; Palladium - administration &amp; dosage ; Palladium - toxicity ; Rats ; Rats, Sprague-Dawley ; Rhodium - administration &amp; dosage ; Rhodium - toxicity ; Sodium - metabolism ; Sodium-Hydrogen Exchangers - drug effects ; Sodium-Potassium-Exchanging ATPase - drug effects ; Sodium-Potassium-Exchanging ATPase - metabolism</subject><ispartof>Comparative biochemistry and physiology. Part C, Pharmacology, toxicology &amp; endocrinology, 1995-07, Vol.111 (3), p.423</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8564782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bikhazi, A B</creatorcontrib><creatorcontrib>Salameh, A</creatorcontrib><creatorcontrib>el-Kasti, M M</creatorcontrib><creatorcontrib>Awar, R A</creatorcontrib><title>Comparative nephrotoxic effects of cis-platinum (II), cis-palladium (II), and cis-rhodium (III) metal coordination compounds in rat kidneys</title><title>Comparative biochemistry and physiology. Part C, Pharmacology, toxicology &amp; endocrinology</title><addtitle>Comp Biochem Physiol C Pharmacol Toxicol Endocrinol</addtitle><description>A Sprague-Dawley rat kidney perfusion technique was used in situ to study the effects of cis-dichloro-diamine platinum, PdCl2 (2,6-diaminopyridine), and RhCl3 (2,6-diaminopyridine) on sodium and calcium retention in the whole kidney. The technique involves perfusion of both kidneys via the abdominal aorta and then through the right and left renal arteries and dorsal aorta. Compared to controls, kidneys perfused independently with the three coordination compounds showed approximately equal to 45% decrease and approximately equal to 117% increase in Na+ and Ca2+ retention, respectively. Perfusates containing the coordination compounds in addition to 15 mM ouabain showed approximately equal to 76% decrease in Na+ and insignificant increase in renal Ca2+ retention. Hence, one can rule out the presence of voltage-gated Ca(2+)-channels at the basolateral side due to membrane depolarization. These results suggest that the three metal coordination compounds showed identical nephrotoxic effects on the handling of Na+ and Ca2+ ions by inhibiting both the Na(+)-Ca(2+)-anti-porter and the Na(+)-H(+)-exchanger with laxing effects on nonvoltage-gated Ca(2+)-channels at the basolateral side. However, their effects on the Na(+)-K(+)-ATPase and the Na(+)-Ca2+ symporter was insignificant.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Antineoplastic Agents - administration &amp; dosage</subject><subject>Antineoplastic Agents - toxicity</subject><subject>Calcium - metabolism</subject><subject>Calcium Channels - drug effects</subject><subject>Calcium Channels - metabolism</subject><subject>Cisplatin - administration &amp; dosage</subject><subject>Cisplatin - toxicity</subject><subject>Female</subject><subject>Ouabain - administration &amp; dosage</subject><subject>Ouabain - pharmacology</subject><subject>Palladium - administration &amp; dosage</subject><subject>Palladium - toxicity</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rhodium - administration &amp; dosage</subject><subject>Rhodium - toxicity</subject><subject>Sodium - metabolism</subject><subject>Sodium-Hydrogen Exchangers - drug effects</subject><subject>Sodium-Potassium-Exchanging ATPase - drug effects</subject><subject>Sodium-Potassium-Exchanging ATPase - metabolism</subject><issn>1367-8280</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNo9kM1KxDAcxHNQ1nX1EYQcXbCQJm2SHqX4UVjwsvclTf5ho20Skq64z-BLW9zV0zA_hhmYC7QsGReFpJJcoeuc3wkhjIlmgRay5pWQdIm-2zBGldTkPgF7iPsUpvDlNAZrQU8ZB4u1y0Uc5og_jPi-69YPJ6SGQRn3z5Q3vzztwx_t1niESQ1Yh5CM83NH8LMZYzh4k7HzeJ7GH854OOYbdGnVkOH2rCu0fX7atq_F5u2lax83RawZLYQBoXmjhWXEVGXdN5bppmxoRaBUlvclNawSABq45NIyJTWxFaVCyL43wFbo7lQbD_0IZheTG1U67s6fsB8oQF3q</recordid><startdate>199507</startdate><enddate>199507</enddate><creator>Bikhazi, A B</creator><creator>Salameh, A</creator><creator>el-Kasti, M M</creator><creator>Awar, R A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>199507</creationdate><title>Comparative nephrotoxic effects of cis-platinum (II), cis-palladium (II), and cis-rhodium (III) metal coordination compounds in rat kidneys</title><author>Bikhazi, A B ; Salameh, A ; el-Kasti, M M ; Awar, R A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p532-7de7c69c7f30d415b9f3c919240e1af6b12d347eece6868f3a8c0f422778bbde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Antineoplastic Agents - administration &amp; dosage</topic><topic>Antineoplastic Agents - toxicity</topic><topic>Calcium - metabolism</topic><topic>Calcium Channels - drug effects</topic><topic>Calcium Channels - metabolism</topic><topic>Cisplatin - administration &amp; dosage</topic><topic>Cisplatin - toxicity</topic><topic>Female</topic><topic>Ouabain - administration &amp; dosage</topic><topic>Ouabain - pharmacology</topic><topic>Palladium - administration &amp; dosage</topic><topic>Palladium - toxicity</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rhodium - administration &amp; dosage</topic><topic>Rhodium - toxicity</topic><topic>Sodium - metabolism</topic><topic>Sodium-Hydrogen Exchangers - drug effects</topic><topic>Sodium-Potassium-Exchanging ATPase - drug effects</topic><topic>Sodium-Potassium-Exchanging ATPase - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Bikhazi, A B</creatorcontrib><creatorcontrib>Salameh, A</creatorcontrib><creatorcontrib>el-Kasti, M M</creatorcontrib><creatorcontrib>Awar, R A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Comparative biochemistry and physiology. Part C, Pharmacology, toxicology &amp; endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bikhazi, A B</au><au>Salameh, A</au><au>el-Kasti, M M</au><au>Awar, R A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative nephrotoxic effects of cis-platinum (II), cis-palladium (II), and cis-rhodium (III) metal coordination compounds in rat kidneys</atitle><jtitle>Comparative biochemistry and physiology. Part C, Pharmacology, toxicology &amp; endocrinology</jtitle><addtitle>Comp Biochem Physiol C Pharmacol Toxicol Endocrinol</addtitle><date>1995-07</date><risdate>1995</risdate><volume>111</volume><issue>3</issue><spage>423</spage><pages>423-</pages><issn>1367-8280</issn><abstract>A Sprague-Dawley rat kidney perfusion technique was used in situ to study the effects of cis-dichloro-diamine platinum, PdCl2 (2,6-diaminopyridine), and RhCl3 (2,6-diaminopyridine) on sodium and calcium retention in the whole kidney. The technique involves perfusion of both kidneys via the abdominal aorta and then through the right and left renal arteries and dorsal aorta. Compared to controls, kidneys perfused independently with the three coordination compounds showed approximately equal to 45% decrease and approximately equal to 117% increase in Na+ and Ca2+ retention, respectively. Perfusates containing the coordination compounds in addition to 15 mM ouabain showed approximately equal to 76% decrease in Na+ and insignificant increase in renal Ca2+ retention. Hence, one can rule out the presence of voltage-gated Ca(2+)-channels at the basolateral side due to membrane depolarization. These results suggest that the three metal coordination compounds showed identical nephrotoxic effects on the handling of Na+ and Ca2+ ions by inhibiting both the Na(+)-Ca(2+)-anti-porter and the Na(+)-H(+)-exchanger with laxing effects on nonvoltage-gated Ca(2+)-channels at the basolateral side. However, their effects on the Na(+)-K(+)-ATPase and the Na(+)-Ca2+ symporter was insignificant.</abstract><cop>United States</cop><pmid>8564782</pmid></addata></record>
fulltext fulltext
identifier ISSN: 1367-8280
ispartof Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1995-07, Vol.111 (3), p.423
issn 1367-8280
language eng
recordid cdi_pubmed_primary_8564782
source ScienceDirect Journals
subjects Analysis of Variance
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - toxicity
Calcium - metabolism
Calcium Channels - drug effects
Calcium Channels - metabolism
Cisplatin - administration & dosage
Cisplatin - toxicity
Female
Ouabain - administration & dosage
Ouabain - pharmacology
Palladium - administration & dosage
Palladium - toxicity
Rats
Rats, Sprague-Dawley
Rhodium - administration & dosage
Rhodium - toxicity
Sodium - metabolism
Sodium-Hydrogen Exchangers - drug effects
Sodium-Potassium-Exchanging ATPase - drug effects
Sodium-Potassium-Exchanging ATPase - metabolism
title Comparative nephrotoxic effects of cis-platinum (II), cis-palladium (II), and cis-rhodium (III) metal coordination compounds in rat kidneys
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T02%3A13%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparative%20nephrotoxic%20effects%20of%20cis-platinum%20(II),%20cis-palladium%20(II),%20and%20cis-rhodium%20(III)%20metal%20coordination%20compounds%20in%20rat%20kidneys&rft.jtitle=Comparative%20biochemistry%20and%20physiology.%20Part%20C,%20Pharmacology,%20toxicology%20&%20endocrinology&rft.au=Bikhazi,%20A%20B&rft.date=1995-07&rft.volume=111&rft.issue=3&rft.spage=423&rft.pages=423-&rft.issn=1367-8280&rft_id=info:doi/&rft_dat=%3Cpubmed%3E8564782%3C/pubmed%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p532-7de7c69c7f30d415b9f3c919240e1af6b12d347eece6868f3a8c0f422778bbde3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/8564782&rfr_iscdi=true