Metabolism of dimethylnitrosamine and 1,2-dimethylhydrazine in cultured human bronchi

The metabolic activation of several chemical classes of procarcinogens is being studied in cultured human bronchi. Previous studies have shown that carcinogenic polynuclear aromatic hydrocarbons are metabolically activated by the bronchial epithelium. In the study reported here, dimethylnitrosamine...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1977-07, Vol.37 (7 Pt 1), p.2309
Main Authors: Harris, C C, Autrup, H, Stoner, G D, McDowell, E M, Trump, B F, Schafer, P
Format: Article
Language:English
Subjects:
Biotransformation
Bronchi - metabolism
Culture Techniques
Dimethylhydrazines - metabolism
Dimethylnitrosamine - metabolism
DNA - metabolism
Guanine - analogs & derivatives
Guanine - metabolism
Humans
Hydrazines - metabolism
Methylation
Mutation
Nitrosamines - metabolism
Protein Binding
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Summary:The metabolic activation of several chemical classes of procarcinogens is being studied in cultured human bronchi. Previous studies have shown that carcinogenic polynuclear aromatic hydrocarbons are metabolically activated by the bronchial epithelium. In the study reported here, dimethylnitrosamine and 1,2-dimethylhydrazine were also found to bind to both cellular DNA and protein. Bronchial DNA was methylated in both the O-6 and N-7 positions of guanine. In addition to polynuclear aromatic hydrocarbons, an aliphatic nitrosamine and a methylhydrazine can now be added to the list of xenobiotic chemical carcinogens metabolized by human bronchus.
ISSN:0008-5472