Clonazepam prophylaxis and busulfan-related myoclonic epilepsy in autografted acute leukemia patients

Department of Biopathology, University La Sapienza, Rome, Italy. A prospective neurological and electroencephalographic (EEG) study was performed in sixteen leukemia patients receiving busulfan (BU) and cyclophosphamide before autologous bone marrow transplantation. All patients were given anticonvu...

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Bibliographic Details
Published in:Haematologica (Roma) 1995-11, Vol.80 (6), p.532-534
Main Authors: Meloni, G, Nasta, L, Pinto, RM, Spalice, A, Raucci, U, Iannetti, P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anticonvulsants - therapeutic use
Biological and medical sciences
Bone Marrow Transplantation
Busulfan - adverse effects
Clonazepam - therapeutic use
Drug toxicity and drugs side effects treatment
Epilepsies, Myoclonic - prevention & control
Female
Humans
Leukemia, Myeloid - therapy
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Toxicity: nervous system and muscle
Transplantation, Autologous
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Summary:Department of Biopathology, University La Sapienza, Rome, Italy. A prospective neurological and electroencephalographic (EEG) study was performed in sixteen leukemia patients receiving busulfan (BU) and cyclophosphamide before autologous bone marrow transplantation. All patients were given anticonvulsant prophylaxis with a combination of phenobarbital (PB) and clonazepam (CLZ). Neurological examination and EEG were performed prior to and soon after completion of BU treatment and were repeated two months later. No tonic-clonic and/or myoclonic convulsions were observed. In two patients, comparison of EEG recorded before and upon completion of BU administration revealed modification of features. EEG re-evaluated two months after BU showed normalization in one of the two patients. BU may trigger both generalized and myoclonic seizures together with EEG abnormalities; PB combined with CLZ may be useful prophylactic treatment.
ISSN:0390-6078
1592-8721