Digital necrosis associated with fenoxazoline poisoning. Apropos of a case and review of the literature

We report the case of a 53 year-old woman with paroxystic hypertension and digital ischemia. The only triggering factor was chronic intoxication by a nasal vasoconstrictor:fenoxazoline. The worsening of the lesions required amputation of the third phalanx of the 3rd and 5th finger and the pulp of th...

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Bibliographic Details
Published in:La revue de medecine interne 1996, Vol.17 (1), p.66
Main Authors: Hauet, T, Ramassamy, A, Badia, P, Julien, N, Robert, R, Touchard, G, Patte, D
Format: Article
Language:fre
Subjects:
Female
Fingers - blood supply
Fingers - pathology
Humans
Imidazoles - poisoning
Ischemia - chemically induced
Middle Aged
Nasal Decongestants - poisoning
Necrosis
Toes - blood supply
Toes - pathology
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Summary:We report the case of a 53 year-old woman with paroxystic hypertension and digital ischemia. The only triggering factor was chronic intoxication by a nasal vasoconstrictor:fenoxazoline. The worsening of the lesions required amputation of the third phalanx of the 3rd and 5th finger and the pulp of the 4th finger of the left hand. The review of literature exhibits association between fenoxazoline intoxication and paroxystic hypertension, myocardial ischemia or stroke, but association between fenoxazoline intoxication and digital ischemia has never been reported. We emphasize the extreme caution necessary with the prescription and the chronic consumption of this kind of drug.
ISSN:0248-8663