Some effects of dieldrin and mirex on Ehrlich ascites tumor cells in vivo and in vitro

The effects of dieldrin and mirex on Ehrlich ascites tumor cells were assessed, using certain in vivo (in mice) and in vitro measurements. Mirex retarded the development of Ehrlich ascites tumor in vivo, but dieldrin did not. Effects of dieldrin on de nova RNA purine synthesis from formate in vivo w...

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Bibliographic Details
Published in:Archives of environmental contamination and toxicology 1977, Vol.5 (3), p.333
Main Authors: Walker, E M, Gale, G R, Atkins, L M, Gadsden, R H
Format: Article
Language:English
Subjects:
Animals
Carcinoma, Ehrlich Tumor - metabolism
Carcinoma, Ehrlich Tumor - physiopathology
Dieldrin - pharmacology
DNA, Neoplasm - biosynthesis
In Vitro Techniques
Insecticides - pharmacology
Male
Mice
Mice, Inbred BALB C
Mirex - pharmacology
Neoplasm Proteins - biosynthesis
Purines - biosynthesis
RNA, Neoplasm - biosynthesis
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Summary:The effects of dieldrin and mirex on Ehrlich ascites tumor cells were assessed, using certain in vivo (in mice) and in vitro measurements. Mirex retarded the development of Ehrlich ascites tumor in vivo, but dieldrin did not. Effects of dieldrin on de nova RNA purine synthesis from formate in vivo were slight, while mirex inhibited the synthesis of both RNA purines. Dieldrin inhibited the in vitro incorporation if thymidine, uridine, and L-leucine into DNA, RNA, and protein, respectively, but mirex was virtually without effect.
ISSN:0090-4341