Famotidine-associated delirium : A series of six cases

Famotidine is a histamine H2-receptor antagonist used in inpatient settings for prevention of stress ulcers and is showing increasing popularity because of its low cost. Although all of the currently available H2-receptor antagonists have shown the propensity to cause delirium, only two previously r...

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Bibliographic Details
Published in:Psychosomatics (Washington, D.C.) D.C.), 1996-07, Vol.37 (4), p.349-355
Main Authors: CATALANO, G, CATALANO, M. C, ALBERTS, V. A
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Coronary Disease - drug therapy
Delirium - chemically induced
Drug toxicity and drugs side effects treatment
Famotidine - adverse effects
Famotidine - pharmacokinetics
Famotidine - therapeutic use
Female
Histamine H2 Antagonists - adverse effects
Histamine H2 Antagonists - pharmacokinetics
Humans
Male
Medical sciences
Pharmacology. Drug treatments
Toxicity: nervous system and muscle
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Summary:Famotidine is a histamine H2-receptor antagonist used in inpatient settings for prevention of stress ulcers and is showing increasing popularity because of its low cost. Although all of the currently available H2-receptor antagonists have shown the propensity to cause delirium, only two previously reported cases have been associated with famotidine. The authors report on six cases of famotidine-associated delirium in hospitalized patients who cleared completely upon removal of famotidine. The pharmacokinetics of famotidine are reviewed, with no change in its metabolism in the elderly population seen. The implications of using famotidine in elderly persons are discussed.
ISSN:0033-3182
1545-7206
DOI:10.1016/S0033-3182(96)71548-7