Identification of aldophosphamide as a metabolite of cyclophosphamide in vitro and in vivo in humans

Aldophosphamide (NSC 254), a putative key metabolite of cyclophosphamide, has now been isolated as a cyanohydrin derivative from an incubation mixture of cyclophosphamide with mouse liver microsomes in vitro and from the plasma of a cyclophosphamide-treated patient. The cyanohydrin has been shown to...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1977-08, Vol.37 (8 Pt 1), p.2538
Main Authors: Fenselau, C, Kan, M N, Rao, S S, Myles, A, Friedman, O M, Colvin, M
Format: Article
Language:English
Subjects:
Aldehydes - isolation & purification
Animals
Chromatography, Gas
Cyclophosphamide - blood
Cyclophosphamide - metabolism
Humans
In Vitro Techniques
Mass Spectrometry
Mice
Microsomes, Liver - metabolism
Nitrogen Mustard Compounds - isolation & purification
Organophosphorus Compounds - isolation & purification
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Summary:Aldophosphamide (NSC 254), a putative key metabolite of cyclophosphamide, has now been isolated as a cyanohydrin derivative from an incubation mixture of cyclophosphamide with mouse liver microsomes in vitro and from the plasma of a cyclophosphamide-treated patient. The cyanohydrin has been shown to be identical with an authenic synthetic sample by mass spectrometry and combined gas chromatography-mass spectrometry.
ISSN:0008-5472