The treatment of cryptosporidiosis in AIDS patients using paromomycin

The authors treated with paromomycin 25 patients, with AIDS and cryptosporidiosis. The drug was given orally in a doses of 500 mg qid, for a period of 14 days. Tolerance was good, with just two cases of mild side-effects. Clinical improvement was obtained in 19 (76%) patients. Parasitological cure,...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 1996-07, Vol.29 (4), p.355
Main Authors: Stefani, H N, Levi, G C, Amato Neto, V, Braz, L M, Azevedo, H D, Pôssa, T A, Silva, N F, de Mendonça, J S, Fernandes, A O
Format: Article
Language:Portuguese
Subjects:
Adult
AIDS-Related Opportunistic Infections - drug therapy
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
Cryptosporidiosis - drug therapy
Diarrhea - drug therapy
Drug Evaluation
Female
HIV-1
Humans
Male
Paromomycin - adverse effects
Paromomycin - therapeutic use
Recurrence
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Summary:The authors treated with paromomycin 25 patients, with AIDS and cryptosporidiosis. The drug was given orally in a doses of 500 mg qid, for a period of 14 days. Tolerance was good, with just two cases of mild side-effects. Clinical improvement was obtained in 19 (76%) patients. Parasitological cure, however, occurred only in a low percentage (25%). In some cases where initial success was observed, recrudescence occurred after some weeks or few months, but with retreatment again clinical improvement was obtained. Even if it does not lead to frequent parasite eradication, the good clinical results and tolerance permit us to consider paromomycin one of the few drugs effective for the treatment of cryptosporidial diarrhea in AIDS patients. Studies with maintainance therapy are indicated.
ISSN:0037-8682