Hepatocyte Nuclear Factor 6, a Transcription Factor that Contains a Novel Type of Homeodomain and a Single cut Domain

Tissue-specific transcription is regulated in part by cell type-restricted proteins that bind to defined sequences in target genes. The DNA-binding domain of these proteins is often evolutionarily conserved. On this basis, liver-enriched transcription factors were classified into five families. We d...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1996-09, Vol.93 (18), p.9460-9464
Main Authors: Lemaigre, Frederic P., Durviaux, Serge M., Truong, Oanh, Lannoy, Vincent J., Hsuan, J. Justin, Rousseau, Guy G.
Format: Article
Language:English
Subjects:
Affinity Labels
Amino Acid Sequence
Animals
Autoradiography
Base Sequence
Binding Sites
Biochemistry
Caenorhabditis elegans
Caenorhabditis elegans - genetics
Cloning, Molecular
Complementary DNA
DNA
DNA - metabolism
Drosophila
Drosophila - genetics
Electrophoresis, Polyacrylamide Gel
Genes
Glucose - metabolism
Hepatocyte Nuclear Factor 6
Hepatocytes
Homeodomain proteins
Homeodomain Proteins - chemistry
Homeodomain Proteins - genetics
Homeodomain Proteins - isolation & purification
Liver
Molecular Sequence Data
Nucleotides
Promoter Regions, Genetic
Proteins
Rats
Sequence Homology, Nucleic Acid
Trans-Activators - chemistry
Trans-Activators - genetics
Trans-Activators - isolation & purification
Transcription factors
Transcription Factors - chemistry
Transcription Factors - genetics
Transcription Factors - isolation & purification
Citations: Items that cite this one
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Description
Summary:Tissue-specific transcription is regulated in part by cell type-restricted proteins that bind to defined sequences in target genes. The DNA-binding domain of these proteins is often evolutionarily conserved. On this basis, liver-enriched transcription factors were classified into five families. We describe here the mammalian prototype of a sixth family, which we therefore call hepatocyte nuclear factor 6 (HNF-6). It activates the promoter of a gene involved in the control of glucose metabolism. HNF-6 contains two different DNA-binding domains. One of these corresponds to a novel type of homeodomain. The other is homologous to the Drosophila cut domain. A similar bipartite sequence is coded by the genome of Caenorhabditis elegans.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.93.18.9460