Immunogenicity of the avirulent strain RV194-2 of the rabies virus in mice

RV194-2 rabies virus, an avirulent mutant of CVS strain, induces an inapparent infection limited to the central nervous system (CNS) in adult mice inoculated intracerebrally. This fact suggest that immune response of the host is able to eliminate the virus in CNS. For this reason, we have studied th...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 1996-11, Vol.29 (6), p.579
Main Authors: Marcovistz, R, Leal, E C, de Matos, D C, de Araújo, H P, Tsiang, H
Format: Article
Language:Portuguese
Subjects:
Animals
Antibodies, Viral - immunology
Brain - immunology
Epitopes - immunology
Interferons - blood
Mice
Mice, Inbred BALB C
Rabies virus - classification
Rabies virus - immunology
Species Specificity
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Summary:RV194-2 rabies virus, an avirulent mutant of CVS strain, induces an inapparent infection limited to the central nervous system (CNS) in adult mice inoculated intracerebrally. This fact suggest that immune response of the host is able to eliminate the virus in CNS. For this reason, we have studied the induction of interferon and the humoral immune responses in BALB/c mice after RV194-2 inoculation. These mice presented high levels of interferon in the plasma and in the brain, with elevated levels of neutralizing antirabies antibodies. The 2-5A synthetase, an enzyme marker of interferon action, was analyzed in the brain of inoculated animals. Its enhancement in parallel to the interferon production in the brain, showed biochemical evidence that this interferon is active. Forty five days after RV194-2 virus inoculation, mice were protected against a challenge with the CVS virulent strain. The results presented herein show that RV194-2 strain has a high level of immunogenicity.
ISSN:0037-8682