Thrombomodulin: physiology and clinical applications (excluding systemic diseases)

Thrombomodulin (TM) is a proteoglycan present on the surface of endothelial and mesothelial cells where it acts as a strong anticoagulant. TM is also located in other cells (keratinocytes, osteoblasts, mononuclear phagocytes...) where it might be involved in cell differentiation or inflammatory proc...

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Bibliographic Details
Published in:La revue de medecine interne 1997, Vol.18 (2), p.119
Main Authors: Karmochkine, M, Boffa, M C
Format: Article
Language:fre
Subjects:
Cardiovascular Diseases - blood
Endothelium
Humans
Infection - blood
Neoplasms - blood
Thrombomodulin - blood
Thrombomodulin - physiology
Online Access:Get full text
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Summary:Thrombomodulin (TM) is a proteoglycan present on the surface of endothelial and mesothelial cells where it acts as a strong anticoagulant. TM is also located in other cells (keratinocytes, osteoblasts, mononuclear phagocytes...) where it might be involved in cell differentiation or inflammatory processes. The damage of endothelial cells releases cleavage fragments. Plasma TM appears to be a marker of endothelium damage. Plasma TM has been investigated in several disorders: it is usually increased in the case of diffuse endothelial damage.
ISSN:0248-8663
DOI:10.1016/S0248-8663(97)84677-2