Nitric oxide response in exhaled air during an incremental exhaustive exercise

• Published in: Journal of applied physiology (1985) 1997-04, Vol.82 (4), p.1311-1318
• Main Authors: Chirpaz-Oddou, M. F, Favre-Juvin, A, Flore, P, Eterradossi, J, Delaire, M, Grimbert, F, Therminarias, A
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Carbon Dioxide - metabolism; Cardiac Output - physiology; Electrocardiography; Exercise - physiology; Female; Fundamental and applied biological sciences. Psychology; Heart Rate - physiology; Humans; Lung - physiology; Male; Nitric Oxide - metabolism; Oxygen Consumption - physiology; Physical Fitness; Sex Characteristics; Space life sciences; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.1997.82.4.1311

M. F. Chirpaz-Oddou 1 , A. Favre-Juvin 1 , P. Flore 1 , J. Eterradossi 1 , M. Delaire 1 , F. Grimbert 2 , and A. Therminarias 1 1  Laboratoire de Physiologie et Service de Médecine du Sport and 2  Unité Mixte de Recherche 5525 du Centre National de Recherche Scientifique, Faculté de Médecine de Grenoble, Université Joseph Fourier, 38700 La Tronche, France Received 25 June 1996; accepted in final form 12 November 1996. Chirpaz-Oddou, M. F., A. Favre-Juvin, P. Flore, J. Eterradossi, M. Delaire, F. Grimbert, and A. Therminarias. Nitric oxide response in exhaled air during an incremental exhaustive exercise. J. Appl. Physiol. 82(4): 1311-1318, 1997. This study examines the response of the exhaled nitric oxide (NO) concentration (C NO ) and the exhaled NO output ( NO ) during incremental exercise and during recovery in six sedentary women, seven sedentary men, and eight trained men. The protocol consisted of increasing the exercise intensity by 30 W every 3 min until exhaustion, followed by 5 min of recovery. Minute ventilation ( E ), oxygen consumption ( O 2 ), carbon dioxide production, heart rate, C NO , and NO were measured continuously. The C NO in exhaled air decreased significantly provided that the exercise intensity exceeded 65% of the peak O 2 . It reached similar values, at exhaustion, in all three groups. The NO increased proportionally with exercise intensity up to exhaustion and decreased rapidly during recovery. At exhaustion, the mean values were significantly higher for trained men than for sedentary men and sedentary women. During exercise, NO correlates well with O 2 , carbon dioxide production, E , and heart rate. For the same submaximal intensity, and thus a given O 2 and probably a similar cardiac output, NO appeared to be similar in all three groups, even if the E was different. These results suggest that, during exercise, NO is mainly related to the magnitude of aerobic metabolism and that this relationship is not affected by gender differences or by noticeable differences in the level of physical training. exhaled nitric oxide; recovery; gender; training 0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society