NEUTRALIZING ANTIVIRAL B CELL RESPONSES

Neutralizing antiviral B cell responses differ in various aspects from the many usually measured B cell responses specific for protein in adjuvants. In particular, such neutralizing antiviral B cell responses are more rapidly induced, reach higher titers, are longer lived, and are efficiently genera...

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Bibliographic Details
Published in:Annual review of immunology 1997-01, Vol.15 (1), p.235-270
Main Authors: Bachmann, Martin F, Zinkernagel, Rolf M
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - biosynthesis
antigen organization
Antigens, Viral
B-Lymphocytes - immunology
Humans
Immunologic Memory
Lymphocyte Activation
Lymphocyte Cooperation
Membrane Glycoproteins
memory
Models, Biological
Neutralization Tests
self/nonself discrimination
Signal Transduction
T cell-independent B cell activation
T-Lymphocytes - immunology
Vesicular stomatitis Indiana virus - immunology
Viral Envelope Proteins - immunology
virus
Virus Diseases - immunology
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Summary:Neutralizing antiviral B cell responses differ in various aspects from the many usually measured B cell responses specific for protein in adjuvants. In particular, such neutralizing antiviral B cell responses are more rapidly induced, reach higher titers, are longer lived, and are efficiently generated without adjuvants. Evidence is summarized here that the repetitiveness of many viral antigens is a key factor responsible for the efficiency of these B cell responses, amplifying B cells early and rapidly for potent IgM responses and also for efficient switching to IgG. The data reviewed indicate that B cells discriminate antigen patterns via the degree of surface Ig-cross-linking and use antigen repetitiveness as a self/nonself discriminator.
ISSN:0732-0582
1545-3278
DOI:10.1146/annurev.immunol.15.1.235