DNA VACCINES

Observations in the early 1990s that plasmid DNA could directly transfect animal cells in vivo sparked exploration of the use of DNA plasmids to induce immune responses by direct injection into animals of DNA encoding antigenic proteins. This method, termed DNA immunization, now has been used to eli...

Full description

Saved in:
Bibliographic Details
Published in:Annual review of immunology 1997-01, Vol.15 (1), p.617-648
Main Authors: Donnelly, John J, Ulmer, Jeffrey B, Shiver, John W, Liu, Margaret A
Format: Article
Language:English
Subjects:
Animals
antibodies
Antibodies, Antinuclear - biosynthesis
Antibody Formation
Antigen Presentation
Autoimmunity
bacteria
Bacterial Infections - immunology
Bacterial Infections - prevention & control
cell-mediated immunity
Disease Models, Animal
Genetic Vectors
Humans
Immune Tolerance
Immunity, Cellular
Immunization
Neoplasms, Experimental - immunology
Neoplasms, Experimental - prevention & control
parasites
Parasitic Diseases - immunology
Parasitic Diseases - prevention & control
Plasmids - genetics
protective immunity
Safety
T-Lymphocytes, Cytotoxic - immunology
T-Lymphocytes, Helper-Inducer - immunology
Vaccines, DNA - adverse effects
Vaccines, DNA - genetics
Vaccines, DNA - pharmacology
Virus Diseases - immunology
Virus Diseases - prevention & control
viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Observations in the early 1990s that plasmid DNA could directly transfect animal cells in vivo sparked exploration of the use of DNA plasmids to induce immune responses by direct injection into animals of DNA encoding antigenic proteins. This method, termed DNA immunization, now has been used to elicit protective antibody and cell-mediated immune responses in a wide variety of preclinical animal models for viral, bacterial, and parasitic diseases. DNA vaccination is particularly useful for the induction of cytotoxic T cells. This review summarizes current knowledge on the vectors, immune responses, immunological mechanisms, safety considerations, and potential for further application of this novel method of immunization.
ISSN:0732-0582
1545-3278
DOI:10.1146/annurev.immunol.15.1.617