Multicomponent Spectroscopic Investigations of Salivary Antioxidant Consumption by an Oral Rinse Preparation Containing the Stable Free Radical Species Chlorine Dioxide (CIO2)

A multicomponent evaluation of the oxidative consumption of salivary biomolecules by a commercially-available oral rinse preparation containing an admixture of the stable free radical species chlorine dioxide (ClO2.) with chlorite anion (ClO2-) has been investigated using high resolution 1H NMR spec...

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Bibliographic Details
Published in:Free radical research 1997-01, Vol.26 (3), p.209-234
Main Authors: Lynch, Edward, Sheerin, Angela, Claxson, Andrew W. D., Atherton, Martin D., Rhodes, Christopher J., Silwood, Christopher J. L., Naughton, Declan P., Grootveld, Martin
Format: Article
Language:English
Subjects:
Absorption
Chlorine - chemistry
Chlorine - pharmacology
Chlorine - therapeutic use
Chlorine Compounds
Chlorine dioxide
chlorite anion
Electron Spin Resonance Spectroscopy
Female
Free Radicals - pharmacology
H NMR
halitosis
human saliva
Humans
Magnetic Resonance Spectroscopy
Male
Models, Chemical
Mouthwashes - chemistry
Mouthwashes - pharmacology
Mouthwashes - therapeutic use
Oxidation-Reduction
Oxides - chemistry
Oxides - pharmacology
Oxides - therapeutic use
Oxygen Consumption - drug effects
periodontology
Saliva - chemistry
Saliva - drug effects
Saliva - metabolism
Spectrum Analysis - methods
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Summary:A multicomponent evaluation of the oxidative consumption of salivary biomolecules by a commercially-available oral rinse preparation containing an admixture of the stable free radical species chlorine dioxide (ClO2.) with chlorite anion (ClO2-) has been investigated using high resolution 1H NMR spectroscopy. The results obtained demonstrated that ClO2. and/or ClO2- present in this preparation effected the oxidative decarboxylation of salivary pyruvate (to acetate and CO2). Experiments conducted on chemical model systems confirmed the oxidative decarboxylation of pyruvate by this oral rinse, and also demonstrated that urate, thiocyanate anion, and the amino acids cysteine and methionine (precursors to volatile sulphur compounds responsible for oral malodour), were oxidatively consumed. The biochemical, periodontal and therapeutic significance of the results are discussed.
ISSN:1071-5762
1029-2470
DOI:10.3109/10715769709097801