Genetic factors influencing alpha-particle-induced chromosomal instability

Alpha-particle-induced chromosomal instability in haemopoietic cells obtained from the CBA/H, DBA/2 and C57BL/6 inbred strains of mouse has been demonstrated at frequencies dependent on genotype. The CBA/H and DBA/2 strains may be regarded as 'sensitive' and the C57BL/6 strain as 'res...

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Bibliographic Details
Published in:International journal of radiation biology 1997, Vol.71 (5), p.497-503
Main Authors: WATSON, G. E, LORIMORE, S. A, CLUTTON, S. M, KADHIM, M. A, WRIGHT, E. G
Format: Article
Language:English
Subjects:
Alpha Particles
Animals
Biological and medical sciences
Cells, Cultured
Chromosome Aberrations
Fundamental and applied biological sciences. Psychology
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Inbred DBA
Molecular and cellular biology
Molecular genetics
Mutagenesis. Repair
Space life sciences
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Summary:Alpha-particle-induced chromosomal instability in haemopoietic cells obtained from the CBA/H, DBA/2 and C57BL/6 inbred strains of mouse has been demonstrated at frequencies dependent on genotype. The CBA/H and DBA/2 strains may be regarded as 'sensitive' and the C57BL/6 strain as 'resistant'; resistance was dominant in cells from F1 hybrids. Previously, in cultures where we demonstrated radiation-induced chromosomal instability we also demonstrated an enhanced and persisting oxyradical activity. Quantitative differences in superoxide generation have now been correlated with genetically determined differences in the expression of chromosomal instability. Our findings demonstrate an important influence of genetic factors in alpha -particle-induced chromosomal instability.
ISSN:0955-3002
1362-3095
DOI:10.1080/095530097143824