Reversal of Long-Standing Iron Deficiency Anaemia after Eradication of Helicobacter pylori Infection

Helicobacter pylori has been proposed as a major determinant in multiple gastric disorders. We describe the case of a young adult with a long-standing medical history of sideropenic anaemia and of oral iron consumption dependence with a chronic superficial H. pylori-positive gastritis. All other cau...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 1997, Vol.32 (6), p.617-622
Main Authors: Marignani, M., Angeletti, S., Bordi, C., Malagnino, F., Mancino, C., Fave, G. Delle, Annibale, B.
Format: Article
Language:English
Subjects:
Adult
Anemia, Iron-Deficiency - etiology
Anemia, Iron-Deficiency - prevention & control
Anemias. Hemoglobinopathies
Anti-Bacterial Agents - therapeutic use
Anti-Ulcer Agents - therapeutic use
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Bismuth - therapeutic use
Clarithromycin - therapeutic use
Diseases of red blood cells
Drug Therapy, Combination
Gastritis
Gastritis - microbiology
Helicobacter Infections - complications
Helicobacter Infections - drug therapy
Helicobacter pylori
Hematologic and hematopoietic diseases
Human bacterial diseases
Humans
Infectious diseases
iron deficiency anaemia
Male
Medical sciences
Metronidazole - therapeutic use
Omeprazole - therapeutic use
Organometallic Compounds - therapeutic use
Salicylates - therapeutic use
Tetracycline - therapeutic use
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Summary:Helicobacter pylori has been proposed as a major determinant in multiple gastric disorders. We describe the case of a young adult with a long-standing medical history of sideropenic anaemia and of oral iron consumption dependence with a chronic superficial H. pylori-positive gastritis. All other causes of sideropenic anaemia were carefully excluded. Histology showed a peculiar pattern of non-active H. pylori-positive gastritis. The bacterium was a non-VacA-producing strain. The first attempt at eradication caused a reduction in bacterial load and led to a partial normalization of haematologic variables without improving the ferritin level. A successful second course of eradication therapy completely reversed the anaemia and restored the iron deposit, which persisted at the 29-month follow-up. H. pylori infection can be involved in unexplained cases of iron deficiency anaemia in adults, and its cure can normalize the haematologic picture.
ISSN:0036-5521
1502-7708
DOI:10.3109/00365529709025109