p53 and CD44 as clinical markers of tumour progression in colorectal carcinogenesis

Recent advances in molecular genetics have importantly improved our understanding of the development of colorectal cancer. The present review gives an overview of the clinical value of the tumour-suppressor gene, p53, and the CD44 cell adhesion molecule in colorectal cancer and the pitfalls encounte...

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Bibliographic Details
Published in:The Histochemical journal 1997-06, Vol.29 (6), p.439
Main Authors: Mulder, J W, Wielenga, V J, Pals, S T, Offerhaus, G J
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - genetics
Adenocarcinoma - metabolism
Biomarkers, Tumor - metabolism
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Disease Progression
Genes, p53 - genetics
Humans
Hyaluronan Receptors - genetics
Hyaluronan Receptors - metabolism
Immunohistochemistry
Prognosis
Tumor Suppressor Protein p53 - metabolism
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Summary:Recent advances in molecular genetics have importantly improved our understanding of the development of colorectal cancer. The present review gives an overview of the clinical value of the tumour-suppressor gene, p53, and the CD44 cell adhesion molecule in colorectal cancer and the pitfalls encountered in the immunohistochemical detection of these proteins. Immunohistochemistry potentially forms a procedure applicable for routine diagnosis and prognostication. Therefore, p53 expression and the independent prognostic importance of CD44v6 expression is given particular emphasis, and other molecular events underlying colorectal carcinogenesis are only mentioned briefly.
ISSN:0018-2214
DOI:10.1023/a:1026403404652