Spectral analysis of a thalamus-to-cortex seizure pathway

Physiological evidence has shown that the anterior thalamus (AN) and its associated efferents/afferents constitute an important propagation pathway for one animal model of generalized tonic clonic epileptic seizures. In this study the authors extend and confirm the support for AN's role by exam...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 1997-08, Vol.44 (8), p.657-664
Main Authors: Sherman, D.L., Yien Che Tsai, Rossell, L.A., Mirski, M.A., Thakor, N.V.
Format: Article
Language:English
Subjects:
Analog-Digital Conversion
Analysis of Variance
Animals
Biological and medical sciences
Brain
Brain modeling
Cerebral Cortex - physiopathology
Coherence
Electroencephalography
Epilepsy
Epilepsy - diagnosis
Frequency
Joining processes
Male
Medical sciences
Models, Neurological
Nervous system involvement in other diseases. Miscellaneous
Neurology
Rats
Rats, Sprague-Dawley
Robustness
Seizures - physiopathology
Signal analysis
Signal processing
Signal Processing, Computer-Assisted
Spectral analysis
Spectrum analysis
Thalamus - physiopathology
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Summary:Physiological evidence has shown that the anterior thalamus (AN) and its associated efferents/afferents constitute an important propagation pathway for one animal model of generalized tonic clonic epileptic seizures. In this study the authors extend and confirm the support for AN's role by examining neuro-electric signal indicators during seizure episodes. They show that the electroencephalogram (EEG) recorded from AN is highly coherent with the EEG derived from the cortex (CTX). By removing the effects of another thalamic nucleus, posterior thalamus (PT)-unaffiliated with the tract linking AN to cortex-partial coherence analysis leaves the CTX/AN coherence undiminished. The most robust band of strong CTX-AN coherence is centered around the spike wave pacing frequency of 1-3 Hz. Partial-multiple coherence analysis techniques are used to remove the possible signal contributions from hippocampus in addition to PT. The CTX-AN coherence still remains undiminished in the low-frequency bands. Conclusive evidence from coherence studies and other spectral measures reaffirm the special role of the AN in the propagation of seizure activity from subcortex to cortex.
ISSN:0018-9294
1558-2531
DOI:10.1109/10.605422