A new measure of xenobiotic toxicity to the fist-line human defence system from the time-resolved phagocyte luminescence

A new measure of toxicity based on stochastic modelling of single photon-counting processes, representing time-resolved phagocyte luminescence of xenobiotic-perturbed human neutrophils, has been constructed. The stochastic measure of toxicity has been verified by the QSAR method, and then compared a...

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Bibliographic Details
Published in:Bulletin of mathematical biology 1997-09, Vol.59 (5), p.897
Main Authors: Kochel, B, Sajewicz, W
Format: Article
Language:English
Subjects:
Humans
Luminescent Measurements
Mathematics
Models, Biological
Neutrophils - drug effects
Neutrophils - physiology
Phagocytes - drug effects
Phagocytes - physiology
Stochastic Processes
Time Factors
Xenobiotics - toxicity
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Summary:A new measure of toxicity based on stochastic modelling of single photon-counting processes, representing time-resolved phagocyte luminescence of xenobiotic-perturbed human neutrophils, has been constructed. The stochastic measure of toxicity has been verified by the QSAR method, and then compared and contrasted with the traditional toxicity measure used in bio- and chemiluminescent research. Phenol and benzene homologues were chosen as perturbers due to their importance from the viewpoint of ecotoxicity and occupational medicine.
ISSN:0092-8240